In vivo models (acute, subchronic and developmental toxicity, bioavailability, mechanism of action, efficacy, etc) are implemented in both rats (Sprague dawley, Wistar,…) and mice (BALB/c, Swiss,…) at the nearby facilities in the campus of the University of Leon. A five- people team at INBIOTEC has been officially accredited in the care and use of laboratory animals for Functions B and C as defined in article 23 of EU Directive 2010/63.