We engage with food and feed industry in the development of tools that improve process control when it comes to biological and toxicological hazards. Another focus is the development of biological-based devices embedded in food packaging as sensing systems for quality and durability checking along the whole supply chain.
Inbiotec: Instituto de biotecnología de León
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Food quality & safety
Related projects:
- 2009 INIA-RM2006-00006-00-00 (2006-2009). “Aislamiento, caracterización genética y conservación de levaduras vínicas autóctonas de la variedad de uva Prieto Picudo (Asociación Vinos de Calidad de Tierras de León, Castilla y León”.
- 2007 DIPUTACIÓN PROVINCIAL DE LEÓN (2004). “Caracterización de las cepas del hongo filamentoso productor de la sustancia acaricida”.
- 2006 AGL2003-00865 (12/2003-11/2006). “Incremento de la calidad de los vinos españoles mediante la eliminación de cloroanisoles del tapón de corcho”. I.P: Dr. Juan José Rubio Coque.
- 2005 DIPUTACIÓN PROVINCIAL DE LEÓN (2002). “Control biológico de los ácaros de la Cecina de León: Producción de un microorganismo acaricida y pruebas en fábrica de su eficiencia”.
- 2003 INIA-SC00-021-C3-3 (2000-2003) “Eliminación de los ácaros del jamón y salazones cárnicas mediante control biológico por mohos entomopatógenos”. I.P. Dr. Juan Francisco Martín Martín.
- 2000 AMINO: Application of novel inhibitors from microorganisms: A new bioprocess for the production of green agrochemicals. FP4-Bioprocessing. Project FAIR-CT97-3140 (01/10/1997-30/09/2000).
- 2000 DIPUTACIÓN PROVINCIAL DE LEÓN (1997-2000). “Caracterización de la flora fúngica de la cecina de León”.
Related publications:
- 2016 Ullán RV, Barreiro C. Bacterial protease as targets to control bacterial growth (Capítulo 6). 2016. En: New weapons to control bacterial growth. Editor: Tomás G. Villa y Miguel Viñas. Editorial: Springer International Publishing. Hardcover ISBN: 978-3-319-28366-1.
- 2015 K. Kosalková, R. Domínguez-Santos, M. Coton, E. Coton, C. García-Estrada, P. Liras & J. F. Martín. A natural short pathway synthesizes roquefortine C but not meleagrin in three different Penicillium roqueforti strains. Applied Microbiology and Biotechnology. doi:10.1007/s00253-015-6676-0.May 2015
- 2014 GARCÍA-ESTRADA C., MARTÍN J.F. (2014) Penicillins. In Biosynthesis and Molecular Genetics of Fungal Secondary Metabolites Vol. I (eds. C. García-Estrada, S Zeilinger and J.F. Martín). Springer US, New York, NY 10013, USA., pp. 17-42. ISBN 978-1-4939-1190-5.
- 2014 Hidalgo PI, Ullán RV, Albillos SM, Montero O, Fernández-Bodega MÁ, García-Estrada C, Fernández-Aguado M, Martín JF. Molecular characterization of the PR-toxin gene cluster in Penicillium roqueforti and Penicillium chrysogenum: cross talk of secondary metabolite pathways. Fungal Genet Biol. 62:11-24. Jan 2014. 24239699
- 2012 Rodríguez-García, A.Alejandre, A. P., ed., (2012), Aplicación de la Biotecnología en la Ciencia Veterinaria, International Marketing and Communication SA, chapter Aplicaciones de la tecnologГa de microarrays o micromatrices, pp. 237–251.
- 2011 García-Estrada, C, Ullán, RV, Albillos, SM, Fernández-Bodega, MÁ, Durek, P, von Döhren, H, Martín, JF, A single cluster of coregulated genes encodes the biosynthesis of the mycotoxins roquefortine C and meleagrin in Penicillium chrysogenum. Chem. Biol. 18:1499-512 Nov 2011. 22118684
- 2011 Recio, E, Alvarez-Rodríguez, ML, Rumbero, A, Garzón, E, Coque, JJ, Destruction of chloroanisoles by using a hydrogen peroxide activated method and its application to remove chloroanisoles from cork stoppers.J. Agric. Food Chem. 59:12589-97 Dec 2011. 22074456
- 2010 Cobos, R, Barreiro, C, Mateos, RM, Coque, JJ, Cytoplasmic- and extracellular-proteome analysis of Diplodia seriata: a phytopathogenic fungus involved in grapevine decline.Proteome Sci 8:46 2010. 20828386
- 2010 Feltrer, R, Alvarez-Rodríguez, ML, Barreiro, C, Godio, RP, Coque, JJ, Characterization of a novel 2,4,6-trichlorophenol-inducible gene encoding chlorophenol O-methyltransferase from Trichoderma longibrachiatum responsible for the formation of chloroanisoles and detoxification of chlorophenols.Fungal Genet. Biol. 47:458-67 May 2010. 20144725
- 2009 Fernández-Bodega, MA, Mauriz, E, Gómez, A, Martín, JF, Proteolytic activity, mycotoxins and andrastin A in Penicillium roqueforti strains isolated from Cabrales, Valdeón and Bejes-Tresviso local varieties of blue-veined cheeses.Int. J. Food Microbiol. 136:18-25 Nov 2009. 19837474
- 2009 García-Rico, RO, Chávez, R, Fierro, F, Martín, JF, Effect of a heterotrimeric G protein alpha subunit on conidia germination, stress response, and roquefortine C production in Penicillium roqueforti.Int. Microbiol. 12:123-9 Jun 2009. 19784932
- 2009 Kosalková, K, García-Estrada, C, Ullán, RV, Godio, RP, Feltrer, R, Teijeira, F, Mauriz, E, Martín, JF, The global regulator LaeA controls penicillin biosynthesis, pigmentation and sporulation, but not roquefortine C synthesis in Penicilliumchrysogenum.Biochimie 91:214-25 Feb 2009. 18952140
- 2008 García-Rico, RO, Fierro, F, Mauriz, E, Gómez, A, Fernández-Bodega, MA, Martín, JF, The heterotrimeric Galpha protein pga1 regulates biosynthesis of penicillin, chrysogenin and roquefortine in Penicillium chrysogenum.Microbiology (Reading, Engl.) 154:3567-78 Nov 2008. 18957609
- 2008 García-Estrada, C, Ullán, RV, Velasco-Conde, T, Godio, RP, Teijeira, F, Vaca, I, Feltrer, R, Kosalková, K, Mauriz, E, Martín, JF, Post-translational enzyme modification by the phosphopantetheinyl transferase is required for lysine and penicillin biosynthesis but not for roquefortine or fatty acid formation in Penicillium chrysogenum. Biochem. J. 415:317-24 Oct 2008. 18558918
- 2008 Pérez-Pertejo, Y, Reguera, RM, Ordóñez, D, Balaña-Fouce, R, Alterations in the glutathione-redox balance induced by the bio-insecticide Spinosad in CHO-K1 and Vero cells.Ecotoxicol. Environ. Saf. 70:251-8 Jun 2008. 17675233
- 2007 Goswami, M, Recio, E, Campoy, S, Martín, JF, Coque, JJ, Environmental significance of O-demethylation of chloroanisoles by soil bacterial isolates as a mechanism that improves the overall biodegradation of chlorophenols.Environ. Microbiol. 9:2512-21 Oct 2007. 17803776
- 2003 Rodríguez Velasco, ML, Calonge Delso, MM, Ordónez Escudero, D, ELISA and HPLC determination of the occurrence of aflatoxin M(1) in raw cow’s milk.Food Addit Contam 20:276-80 Mar 2003. 12623653
- 2002 Calonge M, Pérez-Pertejo Y, Ordóñez C, Reguera RM, Balaña-Fouce R, Ordóñez D. Determinación de residuos de siete insecticidas organofosforados en frutas mediante cromatografía de gases con detector de nitrógeno-fósforo y confirmación por espectrometría de masas. Rev. Toxicol. 2002; 19: 55-60. http://www.redalyc.org/articulo.oa?id=91919201
- 2002 Laich, F, Fierro, F, Martín, JF, Production of penicillin by fungi growing on food products: identification of a complete penicillin gene cluster in Penicillium griseofulvum and a truncated cluster in Penicillium verrucosum.Appl. Environ. Microbiol. 68:1211-9 Mar 2002. 11872470
- 1999 Cubría, JC, Ordóñez, C, Reguera, RM, Tekwani, BL, Balaña-Fouce, R, Ordóñez, D, Early alterations of polyamine metabolism induced after acute administration of clenbuterol in mouse heart.Life Sci. 64:1739-52 1999. 10353628
- 1998 Cepero, M, Cubría, JC, Reguera, R, Balaña-Fouce, R, Ordóñez, C, Ordóñez, D, Plasma and muscle polyamine levels in aerobically exercised rats treated with salbutamol.J. Pharm. Pharmacol. 50:1059-64 Sep 1998. 9811168
- 1998 Cubría, JC, Reguera, R, Balaña-Fouce, R, Ordóñez, C, Ordóñez, D, Polyamine-mediated heart hypertrophy induced by clenbuterol in the mouse.J. Pharm. Pharmacol. 50:91-6 Jan 1998. 9580224