Inbiotec: Instituto de biotecnología de León

Inbiotec: Instituto de biotecnología de León
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Publications

  • Rodríguez-García A, Fernández-Alegre E, Morales A, Sola-Landa A, Lorraine J, Macdonald S, Dovbnya D, Smith MC, Donova M, Barreiro C. Complete genome sequence of ‘Mycobacterium neoaurum‘ NRRL B-3805, an androstenedione (AD) producer for industrial biotransformation of sterols. J Biotechnol. 2016 Mar; 224:64-65. doi:10.1016/j.jbiotec.2016.03.021. PMID: 26988397


  • Barreiro C*, Ullán RV. DNA-synthesizing enzymes as antibacterial targets (Chapter 4). 2016. In: New weapons to control bacterial growth. Editor: Tomás G. Villa y Miguel Viñas. Springer International Publishing. Hardcover ISBN: 978-3-319-28366-1. (*Corresponding author).


  • Ullán RV, Barreiro C. Bacterial protease as targets to control bacterial growth (Capítulo 6). 2016. En: New weapons to control bacterial growth. Editor: Tomás G. Villa y Miguel Viñas. Editorial: Springer International Publishing. Hardcover ISBN: 978-3-319-28366-1.


  • K. Kosalková, R. Domínguez-Santos, M. Coton, E. Coton, C. García-Estrada, P. Liras & J. F. Martín. A natural short pathway synthesizes roquefortine C but not meleagrin in three different Penicillium roqueforti strains. Applied Microbiology and Biotechnology. doi:10.1007/s00253-015-6676-0.May 2015


  • Martínez-Burgo Y, Álvarez-Álvarez R, Rodríguez-García A, Liras P. The Pathway-Specific Regulator ClaR of Streptomyces clavuligerus Has a Global Effect on the Expression of Genes for Secondary Metabolism and Differentiation. Appl Environ Microbiol. 2015 Oct;81(19):6637-48. doi:10.1128/AEM.00916-15.PMID: 26187955


  • Pérez-Redondo R, Sola-Landa A, Rodríguez-García A. Deciphering the Dynamic Transcriptome Employing Microarrays. In: New Trends in Corynebacterium glutamicum: Beyond the Amino Acids. Barreiro C. (ed.), pp. 13-44. Nova Science Publishers, New York, 2015


  • ZEILINGER S., GARCÍA-ESTRADA C., MARTÍN J.F. (2015). Fungal secondary metabolites in the “OMICS” era. In Biosynthesis and molecular genetics of fungal secondary metabolites Vol II. (eds. S Zeilinger, J.F. Martín, C. García-Estrada and). Springer US, New York, NY 10013, USA., pp. 1-12. ISBN 978-1-4939-2530-8.


  • Cruz Z., García-Estrada C., Olabarrieta I., Rainieri S. (2015) Lipid Nanoparticles: Delivery System for Bioactive Food Compounds. In Microencapsulation and Microspheres for Food Applications (ed. L. Sagis). ELSEVIER Ltd, UK, pp. 313-332. ISBN: 978-0-12-800350-3.


  • GARCÍA-ESTRADA C., ULLÁN R.V. (2015). RNAi-mediated gene silencing in the beta-lactam producer fungi Penicillium chrysogenum and Acremonium chrysogenum. In Genetic Transformation Systems in Fungi, Vol. 2 (eds. M.A. Van den Berg and K. Maruthachalam). Springer International Publishing, Switzerland, pp.125-130. ISBN 978-3-319-10502-4.


  • Domínguez-Santos R, García-Estrada C, Kosalková K, Prieto C, Santamarta I, Martín JF. PcFKH1, a novel regulatory factor from the forkhead family, controls the biosynthesis of penicillin in Penicillium chrysogenum. Biochimie. 2015;115:162-76. Epub 2015 Jun 4. 26049046.


  • Barreiro C (Ed, preface). New trends in Corynebacterium glutamicum: beyond the amino acids. 2015. , Nova Science Publishers (New York, USA). ISBN: 978-1-63483-280-9.


  • Barreiro C. Methods in Proteomics applied to Corynebacterium glutamicum. 2015., New trends in Corynebacterium glutamicum: beyond the amino acids.Nova Science Publishers (New York, USA). ISBN: 978-1-63483-280-9.


  • Barreiro C*, Martín JF. Corynebacterium genus, a dual group of clinical and industrial relevant bacteria. 2015.,New trends in Corynebacterium glutamicum: beyond the amino acids., Nova Science Publishers (New York, USA). ISBN: 978-1-63483-280-9. (*Corresponding author).


  • Pérez-Redondo, R.; Sola-Landa, A. & Rodríguez-García, A.Barreiro, C., ed.,  (2015), New Trends in Corynebacterium glutamicum: Beyond the Amino Acids., Nova Science Publishers, New York, chapter Chapter 2: Deciphering the Dynamic Transcriptome Employing Microarrays., pp. 13–44. (Book chapter)


  • Santos-Beneit F, Fernández-Martínez LT, Rodríguez-García A, Martín-Martín S, Ordóñez-Robles M, Yagüe P, Manteca A, Martín JF. Transcriptional response to vancomycin in a highly vancomycin-resistant Streptomyces coelicolor mutant.Future Microbiol. 9(5):603-22.Jul 2014 24957088


  • Fernández-Aguado M, Martín JF, Rodríguez-Castro R, García-Estrada C, Albillos SM, Teijeira F, Ullán RV. New insights into the isopenicillin N transport in Penicillium chrysogenum. Metab Eng. 22: 89-103. Mar 2014. 24480587


  • Salehi-Najafabadi Z, Barreiro C, Rodríguez-García A, Cruz A, López G E & Martín J F The gamma-butyrolactone receptors BulR1 and BulR2 of Streptomyces tsukubaensis: tacrolimus (FK506) and butyrolactone synthetases production control. Appl Microbiol Biotechnol. 98:4919-36. Feb 2014. 24562179


  • Beites T, Rodríguez-García A, Santos-Beneit F, Moradas-Ferreira P, Aparicio JF & Mendes MV. Genome-wide analysis of the regulation of pimaricin production in Streptomyces natalensis by reactive oxygen species. Appl Microbiol Biotechnol. 98: 2231-2241. Jan 2014. 24413916


  • Yagüe P, Rodríguez-García A, López-García MT, Rioseras B, Martín JF, Sánchez J, Manteca A, Transcriptomic analysis of liquid non-sporulating Streptomyces coelicolor cultures demonstrates the existence of a complex differentiation comparable to that occurring in solid sporulating cultures. PLoS One 9:e86296. Jan 2014 24466012


  • Alvarez-Álvarez R, Rodríguez-García A, Santamarta I, Pérez-Redondo R, Prieto-Domínguez A, Martínez-Burgo Y, Liras P. Transcriptomic analysis of Streptomyces clavuligerusΔccaR::tsr: effects of the cephamycin C-clavulanic acid cluster regulator CcaR on global regulation. Microb Biotechnol. 7:221-31. May 2014 24450885


  • Barreiro C, Martínez-Castro M. Trends in the biosynthesis and production of the immunosuppressant tacrolimus (FK506). Jan 2014 24272367


  • Hidalgo PI, Ullán RV, Albillos SM, Montero O, Fernández-Bodega MÁ, García-Estrada C, Fernández-Aguado M, Martín JF. Molecular characterization of the PR-toxin gene cluster in Penicillium roqueforti and Penicillium chrysogenum: cross talk of secondary metabolite pathways. Fungal Genet Biol. 62:11-24. Jan 2014. 24239699


  • Balaña-Fouce R, Alvarez-Velilla R, Fernández-Prada C, García-Estrada C, Reguera RM. Trypanosomatids topoisomerase re-visited. New structural findings and role in drug discovery. Int J Parasitol Drugs Drug Resist. 2014 Aug 24;4(3):326-37. doi: 10.1016/j.ijpddr.2014.07.006. eCollection 2014 Dec. Review. 25516844.


  • Cepeda-García C, Domínguez-Santos R, García-Rico RO, García-Estrada C, Cajiao  A, Fierro F, Martín JF. Direct involvement of the CreA transcription factor in penicillin biosynthesis and expression of the pcbAB gene in Penicillium chrysogenum. Appl Microbiol Biotechnol. 2014 Aug;98(16):7113-24. Epub 2014 May 13. 24818689.


  • GARCÍA-ESTRADA C., MARTÍN J.F. (2014) Penicillins. In Biosynthesis and Molecular Genetics of Fungal Secondary Metabolites Vol. I (eds. C. García-Estrada, S Zeilinger and J.F. Martín). Springer US, New York, NY 10013, USA., pp. 17-42. ISBN 978-1-4939-1190-5.


  • GARCÍA-ESTRADA C., MARTÍN J.F. (2014) Penicillins. In Biosynthesis and Molecular Genetics of Fungal Secondary Metabolites Vol. I (eds. C. García-Estrada, S Zeilinger and J.F. Martín). Springer US, New York, NY 10013, USA., pp. 17-42. ISBN 978-1-4939-1190-5.


  • DOMÍNGUEZ-SANTOS R., MARTÍN J.F., GARCÍA-ESTRADA C. (2013) Regulatory Processes Controlling the Biosynthesis of Beta-lactam Antibiotics in Penicillium chrysogenum and Acremonium chrysogenum. In Recent Developments in Biotechnology (Drug Discovery) Vol. 9 (ed. V.K. Govil). Studium Press LLC, Houston, Texas 77072, USA., Chapter 7, pp. 225-262. ISBN 1-62699-022-0.


  • Álvarez-Álvarez R, Martínez-Burgo Y, Pérez-Redondo R, Braña AF, Martín JF, Liras P. Expression of the endogenous and heterologous clavulanic acid cluster in Streptomyces flavogriseus: why a silent cluster is sleeping. Applied Microbiology Biotechnology 97:9451-63. Nov 2013. 23974366.


  • García-Estrada C, Barreiro C, Jami MS, Martín-González J, Martín JF. The inducers 1,3-diaminopropane and spermidine cause the reprogramming of metabolism in Penicillium chrysogenum, leading to multiple vesicles and penicillin overproduction. Jun 2013 23639845


  • Fernández-Aguado M, Ullán RV, Tejeira F, Rodríguez-Castro R, Martín JF.(2013). A peroxisomal membrane transporter involved in the import of phenylacetic acid for penicillin biosynthesis in Penicillium chrysogenum. Appl Microbiol Biotechnol. 97: 3073-3084. Apr 2013. 23053082


  • Yagüe P, Rodríguez-García A, López-García MT, Martín JF, Rioseras B, Sánchez J, Manteca A. Transcriptomic analysis of Streptomyces coelicolor differentiation in solid sporulating cultures: first compartmentalized and second multinucleated mycelia have different and distinctive transcriptomes. PLoS One 8:e60665. Mar 2013. 23555999


  • Vasco-Cárdenas MF, Baños S, Ramos A, Martín JF, Barreiro C. Proteome response of Corynebacterium glutamicum to high concentration of industrially relevant C4 and C5 dicarboxylic acids. J Proteomics. 2013 Jun 24;85:65-88 23624027


  • Barriuso-Iglesias M, Barreiro C, Sola-Landa A, Martín JF. Transcriptional control of the F0F1-ATP synthase operon of Corynebacterium glutamicum: SigmaH factor binds to its promoter and regulates its expression at different pH values. Microb Biotechnol. 6:178-188.Mar 2013 23298179


  • Sola-Landa A, Rodríguez-García A, Amin R, Wohlleben W, Martín JF. Competition between the GlnR and PhoP regulators for the glnA and amtB promoters in Streptomyces coelicolor. Nucleic Acids Res. 41:1767-1782.Feb 2013 23248009


  • Santos-Beneit F, Rodríguez-García A, Martín JF. Identification of different promoters in the absA1-absA2 two-component system, a negative regulator of antibiotic production in Streptomyces coelicolor. Feb 2013 23247656


  • Martínez-Castro M, Salehi-Najafabadi Z, Romero F, Pérez-Sanchiz R, Fernández-Chimeno RI, Martín JF, Barreiro C. Taxonomy and chemically semi-defined media for the analysis of the tacrolimus producer Streptomyces tsukubaensis. Appl Microbiol Biotechnol. 2013 97(5):2139-52 22990582


  • Robles-Reglero V, Santamarta I, Álvarez-Álvarez R, Martín JF, Liras P. Transcriptional analysis and proteomics of the holomycin gene cluster in overproducer mutants of Streptomyces clavuligerus.J Biotechnol. Jan 2013 23147422


  • Fernández-Aguado, M, Teijeira, F, Martín, JF, Ullán, RV, A vacuolar membrane protein affects drastically the biosynthesis of the ACV tripeptide and the beta-lactam pathway of Penicilliumchrysogenum. Appl Microbiol Biotechnol. 97:795-808. Jan 2013. 22777282


  • Martín J, García-Estrada C, Kosalková K, Ullán RV, Albillos SM, Martín JF., The inducers 1,3-diaminopropane and spermidine produce a drastic increase in the expression of the penicillin biosynthetic genes for prolonged time, mediated by the laeA regulator.Dec 2012 23089625


  • Goranovič D, Blažič M, Magdevska V, Horvat J, Kuščer E, Polak T, Santos-Aberturas J, Miriam Martínez-Castro M, Barreiro C, Mrak P, Kopitar G, Kosec G, Fujs S, Martín JF, Hrvoje P. FK506 biosynthesis is regulated by two positive regulatory elements in Streptomyces tsukubaensis. BMC Microbiology 2012 Oct 19;12(1):238. 23083511


  • Fernández-Aguado, M, Teijeira, F, Martín, JF, Ullán, RV, A vacuolar membrane protein affects drastically the biosynthesis of the ACV tripeptide and the beta-lactam pathway of Penicilliumchrysogenum. Jul 2012. 22777282


  • Barreiro C, Prieto C, Sola-Landa A, Solera E, Martínez-Castro M, Pérez-Redondo R, García-Estrada C, Aparicio JF, Fernández-Martínez LT, Santos-Aberturas J, Salehi-Najafabadi Z, Rodríguez-García A, Tauch A, Martín JF, Draft Genome of Streptomyces tsukubaensis NRRL 18488, the Producer of the Clinically Important Immunosuppressant Tacrolimus (FK506).J. Bacteriol. 194:3756-7 Jul 2012. 22740677


  • Santos-Aberturas, J, Vicente, CM, Payero, TD, Martín-Sánchez, L, Cañibano, C, Martín, JF, Aparicio, JF, Hierarchical Control on Polyene Macrolide Biosynthesis: PimR Modulates Pimaricin Production via the PAS-LuxR Transcriptional Activator PimM.PLoS ONE 7:e38536 2012. 22693644


  • Fernández-Martínez, LT, Santos-Beneit, F, Martín, JF, Is PhoR-PhoP partner fidelity strict? PhoR is required for the activation of the pho regulon in Streptomyces coelicolor.Mol. Genet. Genomics 287:565-73 Jul 2012. 22643908


  • Martín, JF, Santos-Beneit, F, Rodríguez-García, A, Sola-Landa, A, Smith, MC, Ellingsen, TE, Nieselt, K, Burroughs, NJ, Wellington, EM, Transcriptomic studies of phosphate control of primary and secondary metabolism in Streptomyces coelicolor.Appl. Microbiol. Biotechnol. 95:61-75 Jul 2012. 22622839


  • Santos-Beneit, F, Rodríguez-García, A, Martín, JF, Overlapping binding of PhoP and AfsR to the promoter region of glnR in Streptomyces coelicolor.Microbiol Res. 167:532-5.Mar 2012. 22465186


  • Pérez-Redondo, R, Rodríguez-García, A, Botas, A, Santamarta, I, Martín, JF, Liras, P, ArgR of Streptomyces coelicolor is a versatile regulator.PLoS ONE 7:e32697 2012. 22403700


  • Barreiro C, García Estrada C, Martín JF. Proteomics Methodology Applied to the Analysis of Filamentous Fungi – New Trends for an Impressive Diverse Group of Organisms. 2012. pp: 145-178. En: Applications of Tandem mass Spectrometry. Editor: Prasain J; Co editor: Lay Harn G. Editorial: Intech (Rijeka, Croatia). ISBN 978-953-51-0141-3.


  • Guerra, SM, Rodríguez-García, A, Santos-Aberturas, J, Vicente, CM, Payero, TD, Martín, JF, Aparicio, JF, LAL regulators SCO0877 and SCO7173 as pleiotropic modulators of phosphate starvation response and actinorhodin biosynthesis in Streptomyces coelicolor.PLoS ONE 7:e31475 2012. 22363654


  • Barreiro, C, Martín, JF, García-Estrada, C, Proteomics shows new faces for the old penicillin producer Penicilliumchrysogenum.J. Biomed. Biotechnol. 2012:105109 2012. 22318718


  • Domínguez-Santos R., Martín J.F., Kosalková K., Prieto C., Ullán R.V., García-Estrada C. The regulatory factor PcRFX1 controls the expression of the three genes of β-lactam biosynthesis in Penicillium chrysogenum.Fungal Genet Biol. 49:866-881. Nov 2012. 22960281


  • Kosalková, K, García-Estrada, C, Barreiro, C, Flórez, MG, Jami, MS, Paniagua, MA, Martín, JF, Casein phosphopeptides drastically increase the secretion of extracellular proteins in Aspergillusawamori. Proteomics studies reveal changes in the secretory pathway.Microb. Cell Fact. 11:5 2012. 22234238


  • Martín, JF, Ullán, RV, García-Estrada, C, Role of peroxisomes in the biosynthesis and secretion of β-lactams and other secondary metabolites.J. Ind. Microbiol. Biotechnol. 39:367-82 Mar 2012. 22160272


  • Thomas, L, Hodgson, DA, Wentzel, A, Nieselt, K, Ellingsen, TE, Moore, J, Morrissey, ER, Legaie, R, Wohlleben, W, Rodríguez-García, A, Martín, JF, Burroughs, NJ, Wellington, EM, Smith, MC, Metabolic switches and adaptations deduced from the proteomes of Streptomyces coelicolor wild type and phoP mutant grown in batch culture.Mol. Cell Proteomics 11:M111.013797. Feb 2012. 22147733


  • Prieto, C, García-Estrada, C, Lorenzana, D, Martín, JF, NRPSsp: non-ribosomal peptide synthase substrate predictor.Bioinformatics 28:426-7 Feb 2012. 22130593


  • Wu, X, García-Estrada, C, Vaca, I, Martín, JF, Motifs in the C-terminal region of the Penicillium chrysogenum ACV synthetase are essential for valine epimerization and processivity of tripeptide formation.Biochimie 94:354-64 Feb 2012. 21889568


  • Leitão, AL, García-Estrada, C, Ullán, RV, Guedes, SF, Martín-Jiménez, P, Mendes, B, Martín, JF, Penicilliumchrysogenum var. halophenolicum, a new halotolerant strain with potential in the remediation of aromatic compounds in high salt environments.Microbiol. Res. 167:79-89 Jan 2012. 21524896


  • Martín, J.-F.; Sola-Landa, A. & Rodríguez-García, A.Gross, R. & Beier, D., ed.,  (2012), Two-Component Systems in Bacteria, Caister Academic Press, chapter Chapter 15 Two-component Systems in Streptomyces, pp. 315–331.


  • Rodríguez-García, A.Alejandre, A. P., ed.,  (2012), Aplicación de la Biotecnología en la Ciencia Veterinaria, International Marketing and Communication SA, chapter Aplicaciones de la tecnologГ­a de microarrays o micromatrices, pp. 237–251.


  • BARREIRO C., GARCÍA-ESTRADA C., MARTÍN J.F. (2012) Proteomics Methodology Applied to the Analysis of Filamentous Fungi – New Trends for an Impressive Diverse Group of Organisms. In Applications of Tandem mass Spectrometry (Ed. J. Prasain and G. L. Harn). Intech-Open Access Publisher, Rijeka, Croatia., pp. 127-160. ISBN: 978-953-307-870-0.


  • MARTÍN J.F., GARCÍA-ESTRADA C., ULLÁN R.V. (2012) Genes encoding penicillin and cephalosporin biosynthesis in Acremonium chrysogenum: two separate clusters are required for cephalosporin production. In Biotechnology of fungal genes (ed. V.K. Gupta and M. Ayyachamy). Science Publishers (An Imprint of Edenbridge Ltd, British Channel Islands), Enfield, New Hampshire 03478, USA., pp. 113-138. ISBN: 978-1-57808-787-7.


  • García-Estrada C. (2012) Bases moleculares de la producción de antibióticos beta-lactámicos. En Aplicación de la Biotecnología en la Ciencia Veterinaria (ed. Fundación Tomás Pascual y Pilar Gómez-Cuétara y Real Academia de Ciencias Veterinarias). IMC-SA, Madrid 28036, Spain. pp. 57-104. ISBN: 978-84-7867-202-8.


  • García-Estrada, C, Ullán, RV, Albillos, SM, Fernández-Bodega, MÁ, Durek, P, von Döhren, H, Martín, JF, A single cluster of coregulated genes encodes the biosynthesis of the mycotoxins roquefortine C and meleagrin in Penicillium chrysogenum. Chem. Biol. 18:1499-512 Nov 2011. 22118684


  • Recio, E, Alvarez-Rodríguez, ML, Rumbero, A, Garzón, E, Coque, JJ, Destruction of chloroanisoles by using a hydrogen peroxide activated method and its application to remove chloroanisoles from cork stoppers.J. Agric. Food Chem. 59:12589-97 Dec 2011. 22074456


  • Liras P, Santamarta I, Pérez Redondo R. Chapter 9. Clavulanic Acid and Clavams Biosynthesis and Regulation.Streptomyces Molecular Biology and Biotechnology. Norwich(Reino Unido): Editorial: Horizon Scientific Press, 2011. ISBN 978-1-904455-77-6


  • Santos-Aberturas, J, Payero, TD, Vicente, CM, Guerra, SM, Cañibano, C, Martín, JF, Aparicio, JF, Functional conservation of PAS-LuxR transcriptional regulators in polyene macrolide biosynthesis.Metab. Eng. 13:756-67 Nov 2011. 22001323


  • Santos-Beneit, F, Barriuso-Iglesias, M, Fernández-Martínez, LT, Martínez-Castro, M, Sola-Landa, A, Rodríguez-García, A, Martín, JF, The RNA polymerase omega factor RpoZ is regulated by PhoP and has an important role in antibiotic biosynthesis and morphological differentiation in Streptomyces coelicolor.Appl. Environ. Microbiol. 77:7586-94 Nov 2011. 21908625


  • Salehi-Najafabadi Z, Barreiro C, Martínez Castro M, Solera E, Martín JF. Characterization of a gamma-Butyrolactone Receptor of Streptomyces tacrolimicus: Effect on sporulation and tacrolimus biosynthesis. Appl Microbiol Biotechnol. 2011. 92(5): 971-984. 21792593


  • Pérez-Pertejo, Y, Alvarez-Velilla, R, Estrada, CG, Balaña-Fouce, R, Reguera, RM, Leishmania donovani: proteasome-mediated down-regulation of methionine adenosyltransferase.Parasitology 138:1082-92 Aug 2011. 21813028


  • Salehi-Najafabadi, Z, Barreiro, C, Martínez-Castro, M, Solera, E, Martín, JF, Characterisation of a γ-butyrolactone receptor of Streptomycestacrolimicus: effect on sporulation and tacrolimus biosynthesis.Appl. Microbiol. Biotechnol. 92:971-84 Dec 2011. 21792593


  • Martín, J, García-Estrada, C, Rumbero, A, Recio, E, Albillos, SM, Ullán, RV, Martín, JF, Characterization of an autoinducer of penicillin biosynthesis in Penicillium chrysogenum. Appl. Environ. Microbiol. 77:5688-96 Aug 2011. 21724894


  • Teijeira, F, Ullán, RV, Fernández-Aguado, M, Martín, JF, CefR modulates transporters of beta-lactam intermediates preventing the loss of penicillins to the broth and increases cephalosporin production in Acremoniumchrysogenum. Metab. Eng. 13:532-543 Sep 2011. 21704721


  • Santamarta, I, López-García, MT, Kurt, A, Nárdiz, N, Alvarez-Álvarez, R, Pérez-Redondo, R, Martín, JF, Liras, P, Characterization of DNA-binding sequences for CcaR in the cephamycin-clavulanic acid supercluster of Streptomyces clavuligerus.Mol. Microbiol. 81:968-81 Aug 2011. 21696462


  • Yepes, A, Rico, S, Rodríguez-García, A, Santamaría, RI, Díaz, M, Novel two-component systems implied in antibiotic production in Streptomyces coelicolor.PLoS ONE 6:e19980 2011. 21625497


  • Martín JF, Sola-Landa A, Santos Beneit F & Rodríguez-García A Network mechanisms of phosphate control of primary and secondary metabolism. In: Dyson P (ed.) Streptomyces: Molecular Biology and Biotechnology. Chapter 7:137-149. Mar 2011. Caister Academic Press. ISBN: 978-1-904455-77-6


  • Vaca, I, Casqueiro, J, Ullán, RV, Rumbero, A, Chávez, R, Martín, JF, A preparative method for the purification of isopenicillin N from genetically blocked Acremonium chrysogenum strain TD189: studies on the degradation kinetics and storage conditions.J. Antibiot. 64:447-51 Jun 2011. 21522156


  • Santos-Beneit, F, Rodríguez-García, A, Martín, JF, Complex transcriptional control of the antibiotic regulator afsS in Streptomyces: PhoP and AfsR are overlapping, competitive activators.J. Bacteriol. 193:2242-51 May 2011. 21378195


  • Nárdiz, N, Santamarta, I, Lorenzana, LM, Martín, JF, Liras, P, A rhodanese-like protein is highly overrepresented in the mutant S. clavuligerus oppA2::aph: effect on holomycin and other secondary metabolites production.Microb Biotechnol 4:216-25 Mar 2011. 21342467


  • Martín, JF, Sola-Landa, A, Santos-Beneit, F, Fernández-Martínez, LT, Prieto, C, Rodríguez-García, A, Cross-talk of global nutritional regulators in the control of primary and secondary metabolism in Streptomyces.Microb Biotechnol 4:165-74 Mar 2011. 21342462


  • Santos-Aberturas, J, Vicente, CM, Guerra, SM, Payero, TD, Martín, JF, Aparicio, JF, Molecular control of polyene macrolide biosynthesis: direct binding of the regulator PimM to eight promoters of pimaricin genes and identification of binding boxes.J. Biol. Chem. 286:9150-61 Mar 2011. 21187288


  • García-Rico, RO, Martín, JF, Fierro, F, Heterotrimeric Gα protein Pga1 from Penicillium chrysogenum triggers germination in response to carbon sources and affects negatively resistance to different stress conditions.Fungal Genet. Biol. 48:641-9 Jun 2011. 21146624


  • Martínez-Castro, M, Barreiro, C, Romero, F, Fernández-Chimeno, RI, Martín, JF, Streptomyces tacrolimicus sp. nov., a low producer of the immunosuppressant tacrolimus (FK506).Int. J. Syst. Evol. Microbiol. 61:1084-8 May 2011. 20525816


  • Martín, J. F.; Sola-Landa, A.; Santos Beneit, F. & Rodríguez-García, A.Dyson, P., ed.,  (2011), Streptomyces: Molecular Biology and Biotechnology, Caister Academic Press, chapter Chapter 7 Network mechanisms of phosphate control of primary and secondary metabolism, pp. 137–149.


  • Liras P., Santamarta I., Pérez-Redondo R. Dyson P., ed., (2011), Streptomyces: Molecular Biology and Biotechnology, Caister Academic Press, Reino Unido. Chapter 9: Clavulanic Acid and Clavams Biosynthesis and Regulation, pp. 167–178.


  • ALBILLOS S.M., GARCÍA-ESTRADA C., MARTÍN J.F. (2011) Spanish blue cheeses: functional metabolites. In Cheese; Types, Nutrition and Consumption (ed. Frank Columbus). Nova Science Publishers, Inc. Hauppauge, NY. pp. 89-104. ISBN: 978-1-61209-828-9.


  • GARCÍA-ESTRADA C., MARTÍN J.F. (2011) Penicillins and cephalosporins. In Comprehensive Biotechnology (ed. Moo-Young Murray). ELSEVIER, Amsterdam. vol. 3, pp. 255-268. ISBN: 978-0-444-53352-4.


  • Barreiro C, Jami MS, Garcia-Estrada C, Martín JF. Extracellular and cytoplasmic proteomes of Penicillium chrysogenum reveal the evolution of industrial improvements leading to increased penicillin titers. J Biotechnol. 2010. 150, Supplement 1. 82. S0168165610006036


  • Barreiro C, Salehi Z, Martínez-Castro M, Martín JF. Gamma-Butyrolactone and Phosphate-Depletion Related Genes Strongly Influence the Sporulation Process of the Immunosuppressant-Producer Strain Streptomyces sp ATCC 55098. J Biotechnol. 2010. 150, Supplement 1. 390-391. S0168165610014057


  • Martín, JF, Ullán, RV, García-Estrada, C, Regulation and compartmentalization of β-lactam biosynthesis. Microb Biotechnol 3:285-99 May 2010. 21255328


  • Cobos, R, Barreiro, C, Mateos, RM, Coque, JJ, Cytoplasmic- and extracellular-proteome analysis of Diplodia seriata: a phytopathogenic fungus involved in grapevine decline.Proteome Sci 8:46 2010. 20828386


  • Jami, MS, García-Estrada, C, Barreiro, C, Cuadrado, AA, Salehi-Najafabadi, Z, Martín, JF, The Penicillium chrysogenum extracellular proteome. Conversion from a food-rotting strain to a versatile cell factory for white biotechnology.Mol. Cell Proteomics 9:2729-44 Dec 2010. 20823121


  • Ullán, RV, Teijeira, F, Guerra, SM, Vaca, I, Martín, JF, Characterization of a novel peroxisome membrane protein essential for conversion of isopenicillin N into cephalosporin C. Biochem. J. 432:227-36 Dec 2010. 20819073


  • López-García, MT, Santamarta, I, Liras, P, Morphological differentiation and clavulanic acid formation are affected in a Streptomyces clavuligerus adpA-deleted mutant.Microbiology (Reading, Engl.) 156:2354-65 Aug 2010. 20447998


  • Martín, JF, Liras, P, Engineering of regulatory cascades and networks controlling antibiotic biosynthesis in Streptomyces.Curr. Opin. Microbiol. 13:263-73 Jun 2010. 20303823


  • García-Estrada, C, Prada, CF, Fernández-Rubio, C, Rojo-Vázquez, F, Balaña-Fouce, R, DNA topoisomerases in apicomplexan parasites: promising targets for drug discovery.Proc. Biol. Sci. 277:1777-87 Jun 2010. 20200034


  • Jami, MS, Barreiro, C, García-Estrada, C, Martín, JF, Proteome analysis of the penicillin producer Penicillium chrysogenum: characterization of protein changes during the industrial strain improvement.Mol. Cell Proteomics 9:1182-98 Jun 2010. 20154335


  • Feltrer, R, Alvarez-Rodríguez, ML, Barreiro, C, Godio, RP, Coque, JJ, Characterization of a novel 2,4,6-trichlorophenol-inducible gene encoding chlorophenol O-methyltransferase from Trichoderma longibrachiatum responsible for the formation of chloroanisoles and detoxification of chlorophenols.Fungal Genet. Biol. 47:458-67 May 2010. 20144725


  • Pérez-Redondo, R, Santamarta, I, Bovenberg, R, Martín, JF, Liras, P, The enigmatic lack of glucose utilization in Streptomyces clavuligerus is due to inefficient expression of the glucose permease gene.Microbiology (Reading, Engl.) 156:1527-37 May 2010. 20110297


  • Nieselt, K, Battke, F, Herbig, A, Bruheim, P, Wentzel, A, Jakobsen, ØM, Sletta, H, Alam, MT, Merlo, ME, Moore, J, Omara, WA, Morrissey, ER, Juarez-Hermosillo, MA, Rodríguez-García, A, Nentwich, M, Thomas, L, Iqbal, M, Legaie, R, Gaze, WH, Challis, GL, Jansen, RC, Dijkhuizen, L, Rand, DA, Wild, DL, Bonin, M, Reuther, J, Wohlleben, W, Smith, MC, Burroughs, NJ, Martín, JF, Hodgson, DA, Takano, E, Breitling, R, Ellingsen, TE, Wellington, EM, The dynamic architecture of the metabolic switch in Streptomyces coelicolor.BMC Genomics 11:10 2010. 20053288


  • GARCÍA-ESTRADA C., FIERRO F., MARTÍN J.F. (2010) Evolution of fungal β-lactam biosynthesis gene clusters. In Microbiology Book Series number 2: Current Research, Technology and Education Topics in Applied Microbiology and Microbial Biotechnology (Volume 1) (ed. A. Méndez-Villas). FORMATEX RESEARCH CENTER, Badajoz, pp.577-588. ISBN (13): 978-84-614-6194-3.


  • Fernández-Bodega, MA, Mauriz, E, Gómez, A, Martín, JF, Proteolytic activity, mycotoxins and andrastin A in Penicillium roqueforti strains isolated from Cabrales, Valdeón and Bejes-Tresviso local varieties of blue-veined cheeses.Int. J. Food Microbiol. 136:18-25 Nov 2009. 19837474


  • García-Rico, RO, Chávez, R, Fierro, F, Martín, JF, Effect of a heterotrimeric G protein alpha subunit on conidia germination, stress response, and roquefortine C production in Penicillium roqueforti.Int. Microbiol. 12:123-9 Jun 2009. 19784932


  • Teves, F, Lamas-Maceiras, M, García-Estrada, C, Casqueiro, J, Naranjo, L, Ullán, RV, Scervino, JM, Wu, X, Velasco-Conde, T, Martín, JF, Transcriptional upregulation of four genes of the lysine biosynthetic pathway by homocitrate accumulation in Penicillium chrysogenum: homocitrate as a sensor of lysine-pathway distress.Microbiology (Reading, Engl.) 155:3881-92 Dec 2009. 19696106


  • Tunca, S, Barreiro, C, Coque, JJ, Martín, JF, Two overlapping antiparallel genes encoding the iron regulator DmdR1 and the Adm proteins control siderophore [correction of sedephore] and antibiotic biosynthesis in Streptomyces coelicolor A3(2).FEBS J. 276:4814-27 Sep 2009. 19664059


  • Ordóñez, C, Alfonso, J, Balaña-Fouce, R, Ordóñez, D, Functional expression of a DNA-topoisomerase IB from Cryptosporidium parvum.J. Biomed. Biotechnol. 2009:837608 2009. 19644560


  • Vicente, CM, Santos-Aberturas, J, Guerra, SM, Payero, TD, Martín, JF, Aparicio, JF, PimT, an amino acid exporter controls polyene production via secretion of the quorum sensing pimaricin-inducer PI-factor in Streptomyces natalensis.Microb. Cell Fact. 8:33 2009. 19505319


  • García-Estrada, C, Vaca, I, Ullán, RV, van den Berg, MA, Bovenberg, RA, Martín, JF, Molecular characterization of a fungal gene paralogue of the penicillin penDE gene of Penicillium chrysogenum.BMC Microbiol. 9:104 2009. 19470155


  • Martínez-Castro, M, Solera, E, Martín, JF, Barreiro, C, Efficient pyramidal arrangement of an ordered cosmid library: Rapid screening of genes of the tacrolimus-producer Streptomyces sp. ATCC 55098.J. Microbiol. Methods 78:150-4 Aug 2009. 19445977


  • Santos-Beneit, F, Rodríguez-García, A, Apel, AK, Martín, JF, Phosphate and carbon source regulation of two PhoP-dependent glycerophosphodiester phosphodiesterase genes of Streptomyces coelicolor.Microbiology (Reading, Engl.) 155:1800-11 Jun 2009. 19383699


  • Martín, JF, Aparicio, JF, Enzymology of the polyenes pimaricin and candicidin biosynthesis.Meth. Enzymol. 459:215-42 2009. 19362642


  • Fernández-Rubio, C, Ordóñez, C, Abad-González, J, Garcia-Gallego, A, Honrubia, MP, Mallo, JJ, Balaña-Fouce, R, Butyric acid-based feed additives help protect broiler chickens from Salmonella enteritidis infection.Poult. Sci. 88:943-8 May 2009. 19359681


  • Rodríguez-García, A, Sola-Landa, A, Apel, K, Santos-Beneit, F, Martín, JF.Phosphate control over nitrogen metabolism in Streptomyces coelicolor: direct and indirect negative control of glnR, glnA, glnII and amtB expression by the response regulator PhoP.Nucleic Acids Res. 37:3230-42 Jun 2009. 19321498


  • Baños, S, Pérez-Redondo, R, Koekman, B, Liras, P, Glycerol utilization gene cluster in Streptomyces clavuligerus.Appl. Environ. Microbiol. 75:2991-5 May 2009. 19286797


  • Santos-Beneit, F, Rodríguez-García, A, Sola-Landa, A, Martín, JF.Cross-talk between two global regulators in Streptomyces: PhoP and AfsR interact in the control of afsS, pstS and phoRP transcription.Mol. Microbiol. 72:53-68 Apr 2009. 19220751


  • Barreiro, C, Nakunst, D, Hüser, AT, de Paz, HD, Kalinowski, J, Martín, JF, Microarray studies reveal a ‘differential response’ to moderate or severe heat shock of the HrcA- and HspR-dependent systems in Corynebacterium glutamicum.Microbiology (Reading, Engl.) 155:359-72 Feb 2009. 19202085


  • Godio, RP, Martín, JF, Modified oxidosqualene cyclases in the formation of bioactive secondary metabolites: biosynthesis of the antitumor clavaric acid.Fungal Genet. Biol. 46:232-42 Mar 2009. 19130892


  • Rodríguez-Sáiz, M, Godio, RP, Alvarez, V, de la Fuente, JL, Martín, JF, Barredo, JL, The NADP-dependent glutamate dehydrogenase gene from the astaxanthin producer Xanthophyllomyces dendrorhous: use of Its promoter for controlled gene expression.Mol. Biotechnol. 41:165-72 Feb 2009. 19016007


  • Kosalková, K, García-Estrada, C, Ullán, RV, Godio, RP, Feltrer, R, Teijeira, F, Mauriz, E, Martín, JF, The global regulator LaeA controls penicillin biosynthesis, pigmentation and sporulation, but not roquefortine C synthesis in Penicilliumchrysogenum.Biochimie 91:214-25 Feb 2009. 18952140


  • Teijeira, F, Ullán, RV, Guerra, SM, García-Estrada, C, Vaca, I, Martín, JF, The transporter CefM involved in translocation of biosynthetic intermediates is essential for cephalosporin production. Biochem. J. 418:113-24 Feb 2009. 18840096


  • Campoy, S, Álvarez-Rodríguez, ML, Recio, E, Rumbero, A, Coque, JJ, Biodegradation of 2,4,6-TCA by the white-rot fungus Phlebia radiata is initiated by a phase I (O-demethylation)-phase II (O-conjugation) reactions system: implications for the chlorine cycle.Environ. Microbiol. 11:99-110 Jan 2009. 18783381


  • Barriuso-Iglesias, M, Schluesener, D, Barreiro, C, Poetsch, A, Martín, JF, Response of the cytoplasmic and membrane proteome of Corynebacterium glutamicum ATCC 13032 to pH changes.BMC Microbiol. 8:225 2008. 19091079


  • Reguera, RM, Díaz-González, R, Pérez-Pertejo, Y, Balaña-Fouce, R, Characterizing the bi-subunit type IB DNA topoisomerase of Leishmania parasites; a novel scenario for drug intervention in trypanosomatids.Curr Drug Targets 9:966-78 Nov 2008. 18991609


  • García-Rico, RO, Fierro, F, Mauriz, E, Gómez, A, Fernández-Bodega, MA, Martín, JF, The heterotrimeric Galpha protein pga1 regulates biosynthesis of penicillin, chrysogenin and roquefortine in Penicillium chrysogenum.Microbiology (Reading, Engl.) 154:3567-78 Nov 2008. 18957609


  • van den Berg, MA, Albang, R, Albermann, K, Badger, JH, Daran, JM, Driessen, AJ, Garcia-Estrada, C, Fedorova, ND, Harris, DM, Heijne, WH, Joardar, V, Kiel, JA, Kovalchuk, A, Martín, JF, Nierman, WC, Nijland, JG, Pronk, JT, Roubos, JA, van der Klei, IJ, van Peij, NN, Veenhuis, M, von Döhren, H, Wagner, C, Wortman, J, Bovenberg, RA, Genome sequencing and analysis of the filamentous fungus Penicillium chrysogenum.Nat. Biotechnol. 26:1161-8 Oct 2008. 18820685


  • Ullán, RV, Teijeira, F, Martín, JF, Expression of the Acremonium chrysogenum cefT gene in Penicillum chrysogenum indicates that it encodes an hydrophilic beta-lactam transporter.Curr. Genet. 54:153-61 Sep 2008. 18668246


  • Santos-Beneit, F, Rodríguez-García, A, Franco-Domínguez, E, Martín, JF, Phosphate-dependent regulation of the low- and high-affinity transport systems in the model actinomycete Streptomyces coelicolor.Microbiology (Reading, Engl.) 154:2356-70 Aug 2008. 18667568


  • Diaz-González, R, Pérez-Pertejo, Y, Pommier, Y, Balaña-Fouce, R, Reguera, RM, Mutational study of the “catalytic tetrad” of DNA topoisomerase IB from the hemoflagellate Leishmania donovani: Role of Asp-353 and Asn-221 in camptothecin resistance.Biochem. Pharmacol. 76:608-19 Sep 2008. 18655776


  • Aparicio, JF, Martín, JF, Microbial cholesterol oxidases: bioconversion enzymes or signal proteins?Mol Biosyst 4:804-9 Aug 2008. 18633481


  • Balaña-Fouce, R, García-Estrada, C, Pérez-Pertejo, Y, Reguera, RM, Gene disruption of the DNA topoisomerase IB small subunit induces a non-viable phenotype in the hemoflagellate Leishmania major.BMC Microbiol. 8:113 2008. 18611247


  • Ullán, RV, Godio, RP, Teijeira, F, Vaca, I, García-Estrada, C, Feltrer, R, Kosalkova, K, Martín, JF, RNA-silencing in Penicillium chrysogenum and Acremonium chrysogenum: validation studies using beta-lactam genes expression.J. Microbiol. Methods 75:209-18 Oct 2008. 18590779


  • García-Estrada, C, Ullán, RV, Velasco-Conde, T, Godio, RP, Teijeira, F, Vaca, I, Feltrer, R, Kosalková, K, Mauriz, E, Martín, JF, Post-translational enzyme modification by the phosphopantetheinyl transferase is required for lysine and penicillin biosynthesis but not for roquefortine or fatty acid formation in Penicillium chrysogenum. Biochem. J. 415:317-24 Oct 2008. 18558918


  • Liras, P, Gómez-Escribano, JP, Santamarta, I, Regulatory mechanisms controlling antibiotic production in Streptomyces clavuligerus.J. Ind. Microbiol. Biotechnol. 35:667-76 Jul 2008. 18446393


  • García-Estrada, C, Vaca, I, Fierro, F, Sjollema, K, Veenhuis, M, Martín, JF, The unprocessed preprotein form IATC103S of the isopenicillin N acyltransferase is transported inside peroxisomes and regulates its self-processing. Fungal Genet. Biol. 45:1043-52 Jun 2008. 18439860


  • García-Estrada, C, Pérez-Pertejo, Y, Ordóñez, D, Balaña-Fouce, R, Reguera, RM, Characterization of the 5′ region of the Leishmania infantum LORIEN/MAT2 gene cluster and role of LORIEN flanking regions in post-transcriptional regulation.Biochimie 90:1325-36 Sep 2008. 18420039


  • García-Rico, RO, Fierro, F, Martín, JF, Heterotrimeric Galpha protein Pga1 of Penicillium chrysogenum controls conidiation mainly by a cAMP-independent mechanism.Biochem. Cell Biol. 86:57-69 Feb 2008. 18364746


  • Gomez-Escribano, JP, Martín, JF, Hesketh, A, Bibb, MJ, Liras, P, Streptomyces clavuligerus relA-null mutants overproduce clavulanic acid and cephamycin C: negative regulation of secondary metabolism by (p)ppGpp.Microbiology (Reading, Engl.) 154:744-55 Mar 2008. 18310021


  • Martín, JF, Gudiña, E, Barredo, JL, Conversion of beta-carotene into astaxanthin: Two separate enzymes or a bifunctional hydroxylase-ketolase protein?Microb. Cell Fact. 7:3 2008. 18289382


  • Sola-Landa, A, Rodríguez-García, A, Apel, AK, Martín, JF, Target genes and structure of the direct repeats in the DNA-binding sequences of the response regulator PhoP in Streptomyces coelicolor.Nucleic Acids Res. 36:1358-68 Mar 2008. 18187507


  • Pérez-Pertejo, Y, Reguera, RM, Ordóñez, D, Balaña-Fouce, R, Alterations in the glutathione-redox balance induced by the bio-insecticide Spinosad in CHO-K1 and Vero cells.Ecotoxicol. Environ. Saf. 70:251-8 Jun 2008. 17675233


  • Reguera, RM, Pérez-Pertejo, Y, Redondo, CM, Díaz-González, R, Balaña-Fouce, R, [Type I DNA topoisomerase from protozoan pathogens as a potential target for anti-tumoral drugs].Medicina (B Aires) 67:747-57 2007. 18422072


  • Godio, RP, Fouces, R, Martín, JF, A squalene epoxidase is involved in biosynthesis of both the antitumor compound clavaric acid and sterols in the basidiomycete H. sublateritium.Chem. Biol. 14:1334-46 Dec 2007. 18096502


  • Díaz González, R, Pérez Pertejo, Y, Ordóñez, D, Balaña-Fouce, R, Reguera, RM, Deletion study of DNA topoisomerase IB from Leishmania donovani: searching for a minimal functional heterodimer.PLoS ONE 2:e1177 2007. 18000548


  • Kosalková, K, Rodríguez-Sáiz, M, Barredo, JL, Martín, JF, Binding of the PTA1 transcriptional activator to the divergent promoter region of the first two genes of the penicillin pathway in different Penicillium species.Curr. Genet. 52:229-37 Nov 2007. 17924108


  • Apel, AK, Sola-Landa, A, Rodríguez-García, A, Martín, JF, Phosphate control of phoA, phoC and phoD gene expression in Streptomyces coelicolor reveals significant differences in binding of PhoP to their promoter regions.Microbiology (Reading, Engl.) 153:3527-37 Oct 2007. 17906150


  • Díaz González, R, Pérez Pertejo, Y, Redondo, CM, Pommier, Y, Balaña-Fouce, R, Reguera, RM, Structural insights on the small subunit of DNA topoisomerase I from the unicellular parasite Leishmania donovani.Biochimie 89:1517-27 Dec 2007. 17900785


  • Santamarta, I, López-García, MT, Pérez-Redondo, R, Koekman, B, Martín, JF, Liras, P, Connecting primary and secondary metabolism: AreB, an IclR-like protein, binds the ARE(ccaR) sequence of S. clavuligerus and modulates leucine biosynthesis and cephamycin C and clavulanic acid production.Mol. Microbiol. 66:511-24 Oct 2007. 17877708


  • Goswami, M, Recio, E, Campoy, S, Martín, JF, Coque, JJ, Environmental significance of O-demethylation of chloroanisoles by soil bacterial isolates as a mechanism that improves the overall biodegradation of chlorophenols.Environ. Microbiol. 9:2512-21 Oct 2007. 17803776


  • Antón, N, Santos-Aberturas, J, Mendes, MV, Guerra, SM, Martín, JF, Aparicio, JF, PimM, a PAS domain positive regulator of pimaricin biosynthesis in Streptomyces natalensis.Microbiology (Reading, Engl.) 153:3174-83 Sep 2007. 17768260


  • Orchard, S, Salwinski, L, Kerrien, S, Montecchi-Palazzi, L, Oesterheld, M, Stümpflen, V, Ceol, A, Chatr-aryamontri, A, Armstrong, J, Woollard, P, Salama, JJ, Moore, S, Wojcik, J, Bader, GD, Vidal, M, Cusick, ME, Gerstein, M, Gavin, AC, Superti-Furga, G, Greenblatt, J, Bader, J, Uetz, P, Tyers, M, Legrain, P, Fields, S, Mulder, N, Gilson, M, Niepmann, M, Burgoon, L, De Las Rivas, J, Prieto, C, Perreau, VM, Hogue, C, Mewes, HW, Apweiler, R, Xenarios, I, Eisenberg, D, Cesareni, G, Hermjakob, H, The minimum information required for reporting a molecular interaction experiment (MIMIx).Nat. Biotechnol. 25:894-8 Aug 2007. 17687370


  • Rodríguez-García, A, Barreiro, C, Santos-Beneit, F, Sola-Landa, A, Martín, JF, Genome-wide transcriptomic and proteomic analysis of the primary response to phosphate limitation in Streptomyces coelicolor M145 and in a ΔphoP mutant.Proteomics 7:2410-29 Jul 2007. 17623301


  • Balaña-Fouce, R, Reguera, RM, RNA interference in Trypanosoma brucei: a high-throughput engine for functional genomics in trypanosomatids?Trends Parasitol. 23:348-51 Aug 2007. 17604223


  • García-Estrada, C, Vaca, I, Lamas-Maceiras, M, Martín, JF.In vivo transport of the intermediates of the penicillin biosynthetic pathway in tailored strains of Penicilliumchrysogenum.Appl. Microbiol. Biotechnol. 76:169-82 Aug 2007. 17516062


  • García-Rico, RO, Martín, JF, Fierro, F, The pga1 gene of Penicillium chrysogenum NRRL 1951 encodes a heterotrimeric G protein alpha subunit that controls growth and development.Res. Microbiol. 158:437-46 Jun 2007. 17467244


  • Ullán, RV, Campoy, S, Casqueiro, J, Fernández, FJ, Martín, JF, Deacetylcephalosporin C production in Penicillium chrysogenum by expression of the isopenicillin N epimerization, ring expansion, and acetylation genes.Chem. Biol. 14:329-39 Mar 2007. 17379148


  • Mendes, MV, Recio, E, Antón, N, Guerra, SM, Santos-Aberturas, J, Martín, JF, Aparicio, JF, Cholesterol oxidases act as signaling proteins for the biosynthesis of the polyene macrolide pimaricin.Chem. Biol. 14:279-90 Mar 2007. 17379143


  • Tunca, S, Barreiro, C, Sola-Landa, A, Coque, JJ, Martín, JF, Transcriptional regulation of the desferrioxamine gene cluster of Streptomyces coelicolor is mediated by binding of DmdR1 to an iron box in the promoter of the desA gene.FEBS J. 274:1110-22 Feb 2007. 17257267


  • García-Estrada, C, Pérez-Pertejo, Y, Ordóñez, D, Balaña-Fouce, R, Reguera, RM, Analysis of genetic elements regulating the methionine adenosyltransferase gene in Leishmania infantum.Gene 389:163-73 Mar 2007. 17196769


  • Martínez-Valladares, M, Godio-Fernández, R, Vara-Del Río, MP, Martín, JF, Rojo-Vázquez, FA, Expression of the recombinant protein disulphide isomerase of Teladorsagia circumcincta.Parasite Immunol. 29:47-56 Jan 2007. 17187654


  • Mendes, MV, Tunca, S, Antón, N, Recio, E, Sola-Landa, A, Aparicio, JF, Martín, JF, The two-component phoR-phoP system of Streptomyces natalensis: Inactivation or deletion of phoP reduces the negative phosphate regulation of pimaricin biosynthesis.Metab. Eng. 9:217-27 Mar 2007. 17142079


  • GARCÍA-ESTRADA C., MARTÍN J.F. (2007) Penicillin biosynthesis and Secretion: Precursor and Enzyme Localization. In Mycotechnology: Present Status and Future Prospects (ed. Mahendra Rai). I.K. International Publishing House Pvt Ltd, New Delhi, pp.55-83. ISBN 81-89866-08-7.


  • Recio, E, Aparicio, JF, Rumbero, A, Martín, JF, Glycerol, ethylene glycol and propanediol elicit pimaricin biosynthesis in the PI-factor-defective strain Streptomyces natalensis npi287 and increase polyene production in several wild-type actinomycetes.Microbiology (Reading, Engl.) 152:3147-56 Oct 2006. 17005993


  • Gomez-Escribano, JP, Liras, P, Pisabarro, A, Martín, JF, An rplKDelta29-PALG-32 mutation leads to reduced expression of the regulatory genes ccaR and claR and very low transcription of the ceaS2 gene for clavulanic acid biosynthesis in Streptomyces clavuligerus.Mol. Microbiol. 61:758-70 Aug 2006. 16803595


  • Rodríguez-García, A, Santamarta, I, Pérez-Redondo, R, Martín, JF, Liras, P, Characterization of a two-gene operon epeRA involved in multidrug resistance in Streptomyces clavuligerus.Res. Microbiol. 157:559-68. 2006 Jul-Aug.16797928


  • Reguera, RM, Redondo, CM, Gutierrez de Prado, R, Pérez-Pertejo, Y, Balaña-Fouce, R, DNA topoisomerase I from parasitic protozoa: a potential target for chemotherapy.Biochim. Biophys. Acta 1759:117-31. 16757380


  • Fierro, F, García-Estrada, C, Castillo, NI, Rodríguez, R, Velasco-Conde, T, Martín, JF, Transcriptional and bioinformatic analysis of the 56.8 kb DNA region amplified in tandem repeats containing the penicillin gene cluster in Penicillium chrysogenum.Fungal Genet. Biol. 43:618-29 Sep 2006. 16713314


  • Liras, P, Martín, JF, Gene clusters for beta-lactam antibiotics and control of their expression: why have clusters evolved, and from where did they originate?Int. Microbiol. 9:9-19 Mar 2006. 16636985


  • Enríquez, LL, Mendes, MV, Antón, N, Tunca, S, Guerra, SM, Martín, JF, Aparicio, JF, An efficient gene transfer system for the pimaricin producer Streptomyces natalensis.FEMS Microbiol. Lett. 257:312-8 Apr 2006. 16553869


  • Alvarez, V, Rodríguez-Sáiz, M, de la Fuente, JL, Gudiña, EJ, Godio, RP, Martín, JF, Barredo, JL, The crtS gene of Xanthophyllomyces dendrorhous encodes a novel cytochrome-P450 hydroxylase involved in the conversion of beta-carotene into astaxanthin and other xanthophylls.Fungal Genet. Biol. 43:261-72 Apr 2006. 16455271


  • Barriuso-Iglesias, M, Barreiro, C, Flechoso, F, Martín, JF, Transcriptional analysis of the F0F1 ATPase operon of Corynebacterium glutamicum ATCC 13032 reveals strong induction by alkaline pH.Microbiology (Reading, Engl.) 152:11-21 Jan 2006. 16385111


  • Castillo, NI, Fierro, F, Gutiérrez, S, Martín, JF, Genome-wide analysis of differentially expressed genes from Penicillium chrysogenum grown with a repressing or a non-repressing carbon source.Curr. Genet. 49:85-96 Feb 2006. 16362424


  • Lamas-Maceiras, M, Vaca, I, Rodríguez, E, Casqueiro, J, Martín, JF, Amplification and disruption of the phenylacetyl-CoA ligase gene of Penicillium chrysogenum encoding an aryl-capping enzyme that supplies phenylacetic acid to the isopenicillin N-acyltransferase.Biochem. J. 395:147-55 Apr 2006. 16321143


  • Pérez-Pertejo, Y, Reguera, RM, Ordóñez, D, Balaña-Fouce, R, Characterization of a methionine adenosyltransferase over-expressing strain in the trypanosomatid Leishmania donovani.Biochim. Biophys. Acta 1760:10-9 Jan 2006. 16280200


  • Campoy, S, Rumbero, A, Martín, JF, Liras, P, Characterization of an hyperpigmenting mutant of Monascus purpureus IB1: identification of two novel pigment chemical structures.Appl. Microbiol. Biotechnol. 70:488-96 Apr 2006. 16151799


  • Naranjo, L, Lamas-Maceiras, M, Ullán, RV, Campoy, S, Teijeira, F, Casqueiro, J, Martín, JF, Characterization of the oat1 gene of Penicillium chrysogenum encoding an omega-aminotransferase: induction by L-lysine, L-ornithine and L-arginine and repression by ammonium.Mol. Genet. Genomics. 274:283-94 Oct 2005. 16163487


  • Valmaseda, EM, Campoy, S, Naranjo, L, Casqueiro, J, Martín, JF, Lysine is catabolized to 2-aminoadipic acid in Penicillium chrysogenum by an omega-aminotransferase and to saccharopine by a lysine 2-ketoglutarate reductase. Characterization of the omega-aminotransferase.Mol. Genet. Genomics 274:272-82 Oct 2005. 16049680


  • Martín, JF, Casqueiro, J, Liras, P, Secretion systems for secondary metabolites: how producer cells send out messages of intercellular communication.Curr. Opin. Microbiol. 8:282-93 Jun 2005. 15939351


  • Aparicio, JF, Generating novel polyene antifungal drugs.Chem. Biol. 12:509-10 May 2005. 15911369


  • Reguera, RM, Tekwani, BL, Balaña-Fouce, R, Polyamine transport in parasites: a potential target for new antiparasitic drug development.Comp. Biochem. Physiol. C Toxicol. Pharmacol. 140:151-64 Feb 2005. 15907761


  • Sola-Landa, A, Rodríguez-García, A, Franco-Domínguez, E, Martín, JF, Binding of PhoP to promoters of phosphate-regulated genes in Streptomyces coelicolor: identification of PHO boxes.Mol. Microbiol. 56:1373-85 Jun 2005. 15882427


  • Santamarta, I, Pérez-Redondo, R, Lorenzana, LM, Martín, JF, Liras, P, Different proteins bind to the butyrolactone receptor protein ARE sequence located upstream of the regulatory ccaR gene of Streptomyces clavuligerus.Mol. Microbiol. 56:824-35 May 2005. 15819635


  • Flores, FJ, Barreiro, C, Coque, JJ, Martín, JF, Functional analysis of two divalent metal-dependent regulatory genes dmdR1 and dmdR2 in Streptomyces coelicolor and proteome changes in deletion mutants.FEBS J. 272:725-35 Feb 2005. 15670153


  • Barreiro, C, González-Lavado, E, Brand, S, Tauch, A, Martín, JF, Heat shock proteome analysis of wild-type Corynebacterium glutamicum ATCC 13032 and a spontaneous mutant lacking GroEL1, a dispensable chaperone.J. Bacteriol. 187:884-9 Feb 2005. 15659666


  • Mendes, MV, Antón, N, Martín, JF, Aparicio, JF, Characterization of the polyene macrolide P450 epoxidase from Streptomyces natalensis that converts de-epoxypimaricin into pimaricin.Biochem. J. 386:57-62 Feb 2005. 15228385


  • Martín, JF, Ullán, RV, Casqueiro, J, Novel genes involved in cephalosporin biosynthesis: the three-component isopenicillin N epimerase system. Adv. Biochem. Eng. Biotechnol. 88:91-109 2004. 15719553


  • Ullán, RV, Casqueiro, J, Naranjo, L, Vaca, I, Martín, JF, Expression of cefD2 and the conversion of isopenicillin N into penicillin N by the two-component epimerase system are rate-limiting steps in cephalosporin biosynthesis. Mol. Genet. Genomics 272:562-70 Dec 2004. 15668772


  • Godio, RP, Fouces, R, Gudiña, EJ, Martín, JF, Agrobacterium tumefaciens-mediated transformation of the antitumor clavaric acid-producing basidiomycete Hypholoma sublateritium.Curr. Genet. 46:287-94 Nov 2004. 15480676


  • de la Fuente, A, Martín, JF, Rodríguez-García, A, Liras, P, Two proteins with ornithine acetyltransferase activity show different functions in Streptomyces clavuligerus: Oat2 modulates clavulanic acid biosynthesis in response to arginine.J. Bacteriol. 186:6501-7 Oct 2004. 15375131


  • Lombraña, M, Moralejo, FJ, Pinto, R, Martín, JF, Modulation of Aspergillus awamori thaumatin secretion by modification of bipA gene expression.Appl. Environ. Microbiol. 70:5145-52 Sep 2004. 15345393


  • Martín, JF, Phosphate control of the biosynthesis of antibiotics and other secondary metabolites is mediated by the PhoR-PhoP system: an unfinished story.J. Bacteriol. 186:5197-201 Aug 2004. 15292120


  • Recio, E, Colinas, A, Rumbero, A, Aparicio, JF, Martín, JF, PI factor, a novel type quorum-sensing inducer elicits pimaricin production in Streptomyces natalensis.J. Biol. Chem. 279:41586-93 Oct 2004. 15231842


  • Barreiro, C, González-Lavado, E, Pátek, M, Martín, JF, Transcriptional analysis of the groES-groEL1, groEL2, and dnaK genes in Corynebacterium glutamicum: characterization of heat shock-induced promoters.J. Bacteriol. 186:4813-7 Jul 2004. 15231814


  • Pérez-Pertejo, Y, Reguera, RM, García-Estrada, C, Balaña-Fouce, R, Ordóñez, D, Mutational analysis of methionine adenosyltransferase from Leishmania donovani.Eur. J. Biochem. 271:2791-8 Jul 2004. 15206944


  • Aparicio, JF, Mendes, MV, Antón, N, Recio, E, Martín, JF, Polyene macrolide antibiotic biosynthesis.Curr. Med. Chem. 11:1645-56 Jun 2004. 15180569


  • Lorenzana, LM, Pérez-Redondo, R, Santamarta, I, Martín, JF, Liras, P, Two oligopeptide-permease-encoding genes in the clavulanic acid cluster of Streptomyces clavuligerus are essential for production of the beta-lactamase inhibitor.J. Bacteriol. 186:3431-8 Jun 2004. 15150229


  • Fernández, M, Cuadrado, Y, Aparicio, JF, Martín, JF, Role of homoserine and threonine pathway intermediates as precursors for the biosynthesis of aminoethoxyvinylglycine in Streptomyces sp. NRRL 5331.Microbiology (Reading, Engl.) 150:1467-74 May 2004. 15133108


  • Antón, N, Mendes, MV, Martín, JF, Aparicio, JF, Identification of PimR as a positive regulator of pimaricin biosynthesis in Streptomyces natalensis.J. Bacteriol. 186:2567-75 May 2004. 15090496


  • Flores, FJ, Martín, JF, Iron-regulatory proteins DmdR1 and DmdR2 of Streptomyces coelicolor form two different DNA-protein complexes with iron boxes.Biochem. J. 380:497-503 Jun 2004. 14960152


  • Naranjo, L, Martín de Valmaseda, E, Casqueiro, J, Ullán, RV, Lamas-Maceiras, M, Bañuelos, O, Martín, JF, Inactivation of the lys7 gene, encoding saccharopine reductase in Penicillium chrysogenum, leads to accumulation of the secondary metabolite precursors piperideine-6-carboxylic acid and pipecolic acid from alpha-aminoadipic acid.Appl. Environ. Microbiol. 70:1031-9 Feb 2004. 14766586


  • Fierro, F, Laich, F, García-Rico, RO, Martín, JF, High efficiency transformation of Penicillium nalgiovense with integrative and autonomously replicating plasmids.Int. J. Food Microbiol. 90:237-48 Jan 2004. 14698104


  • Cuadrado, Y, Fernández, M, Recio, E, Aparicio, JF, Martín, JF, Characterization of the ask-asd operon in aminoethoxyvinylglycine-producing Streptomyces sp. NRRL 5331.Appl. Microbiol. Biotechnol. 64:228-36 Apr 2004. 14556040


  • Villa, H, Pérez-Pertejo, Y, García-Estrada, C, Reguera, RM, Requena, JM, Tekwani, BL, Balaña-Fouce, R, Ordóñez, D, Molecular and functional characterization of adenylate kinase 2 gene from Leishmania donovani.Eur. J. Biochem. 270:4339-47 Nov 2003. 14622299


  • García-Estrada, C, Reguera, RM, Villa, H, Requena, JM, Müller, S, Pérez-Pertejo, Y, Balaña-Fouce, R, Ordóñez, D, Identification of a gene in Leishmania infantum encoding a protein that contains a SP-RING/MIZ zinc finger domain.Biochim. Biophys. Acta 1629:44-52 Oct 2003. 14522079


  • Bañuelos, O, Naranjo, L, Casqueiro, J, Gutiérrez, S, Martín, JF, Co-transformation with autonomous replicating and integrative plasmids in Penicillium chrysogenum is highly efficient and leads in some cases to rescue of the intact integrative plasmid.Fungal Genet. Biol. 40:83-92 Nov 2003. 14516761


  • Laich, F, Fierro, F, Martin, JF, Isolation of Penicillium nalgiovense strains impaired in penicillin production by disruption of the pcbAB gene and application as starters on cured meat products.Mycol. Res. 107:717-26 Jun 2003. 12951798


  • Martín, JF, Barreiro, C, González-Lavado, E, Barriuso, M, Ribosomal RNA and ribosomal proteins in corynebacteria.J. Biotechnol. 104:41-53 Sep 2003. 12948628


  • Campoy, S, Pérez, F, Martín, JF, Gutiérrez, S, Liras, P, Stable transformants of the azaphilone pigment-producing Monascus purpureus obtained by protoplast transformation and Agrobacterium-mediated DNA transfer.Curr. Genet. 43:447-52 Sep 2003. 12838368


  • Flores, FJ, Rincón, J, Martín, JF, Characterization of the iron-regulated desA promoter of Streptomyces pilosus as a system for controlled gene expression in actinomycetes.Microb. Cell Fact. 2:5 May 2003. 12801423


  • Cardoza, RE, Gutiérrez, S, Ortega, N, Colina, A, Casqueiro, J, Martín, JF, Expression of a synthetic copy of the bovine chymosin gene in Aspergillus awamori from constitutive and pH-regulated promoters and secretion using two different pre-pro sequences.Biotechnol. Bioeng. 83:249-59 Aug 2003. 12783481


  • Sola-Landa, A, Moura, RS, Martín, JF, The two-component PhoR-PhoP system controls both primary metabolism and secondary metabolite biosynthesis in Streptomyces lividans.Proc. Natl. Acad. Sci. U.S.A. 100:6133-8 May 2003. 12730372


  • Fernández, FJ, Cardoza, RE, Montenegro, E, Velasco, J, Gutiérrez, S, Martín, JF, The isopenicillin N acyltransferases of Aspergillus nidulans and Penicillium chrysogenum differ in their ability to maintain the 40-kDa alphabeta heterodimer in an undissociated form.Eur. J. Biochem. 270:1958-68 May 2003. 12709055


  • Aparicio, JF, Caffrey, P, Gil, JA, Zotchev, SB, Polyene antibiotic biosynthesis gene clusters.Appl. Microbiol. Biotechnol. 61:179-88 May 2003. 12698274


  • Rodríguez Velasco, ML, Calonge Delso, MM, Ordónez Escudero, D, ELISA and HPLC determination of the occurrence of aflatoxin M(1) in raw cow’s milk.Food Addit Contam 20:276-80 Mar 2003. 12623653


  • Hijarrubia, MJ, Aparicio, JF, Martín, JF, Domain structure characterization of the multifunctional alpha-aminoadipate reductase from Penicillium chrysogenum by limited proteolysis. Activation of alpha-aminoadipate does not require the peptidyl carrier protein box or the reduction domain.J. Biol. Chem. 278:8250-6 Mar 2003. 12509419


  • Pérez-Pertejo, Y, Reguera, RM, Villa, H, García-Estrada, C, Balaña-Fouce, R, Pajares, MA, Ordóñez, D, Leishmania donovani methionine adenosyltransferase. Role of cysteine residues in the recombinant enzyme.Eur. J. Biochem. 270:28-35 Jan 2003. 12492472


  • Villa, H, Otero Marcos, AR, Reguera, RM, Balaña-Fouce, R, García-Estrada, C, Pérez-Pertejo, Y, Tekwani, BL, Myler, PJ, Stuart, KD, Bjornsti, MA, Ordóñez, D, A novel active DNA topoisomerase I in Leishmania donovani.J. Biol. Chem. 278:3521-6 Feb 2003. 12444094


  • PÉREZ-PERTEJO, Y., DÍAZ-GONZÁLEZ, R., GARCÍA-ESTRADA, C., REGUERA, R. M. AND BALAÑA-FOUCE, R. (2003) S-adenosylmethionine metabolism in Leishmania parasites. Recent Research Developments in Microbiology. Ed. S.G. Pandalai, Research Signpost, Vol. 7. Part II: 547-560.

    • Year: 2003
    • Related applications: Health


  • Martín, JF, Demain, AL, Unraveling the methionine-cephalosporin puzzle in Acremonium chrysogenum.Trends Biotechnol. 20:502-7 Dec 2002. 12443871


  • de la Fuente, A, Lorenzana, LM, Martín, JF, Liras, P, Mutants of Streptomyces clavuligerus with disruptions in different genes for clavulanic acid biosynthesis produce large amounts of holomycin: possible cross-regulation of two unrelated secondary metabolic pathways.J. Bacteriol. 184:6559-65 Dec 2002. 12426344


  • Ullan, RV, Casqueiro, J, Banuelos, O, Fernandez, FJ, Gutierrez, S, Martin, JF, A novel epimerization system in fungal secondary metabolism involved in the conversion of isopenicillin N into penicillin N in Acremonium chrysogenum.J. Biol. Chem. 277:46216-25 Nov 2002. 12228250


  • Ullán, RV, Liu, G, Casqueiro, J, Gutiérrez, S, Bañuelos, O, Martín, JF, The cefT gene of Acremonium chrysogenum C10 encodes a putative multidrug efflux pump protein that significantly increases cephalosporin C production.Mol. Genet. Genomics 267:673-83 Jul 2002. 12172807


  • Hijarrubia, MJ, Aparicio, JF, Martín, JF, Nitrate regulation of alpha-aminoadipate reductase formation and lysine inhibition of its activity in Penicillium chrysogenum and Acremonium chrysogenum.Appl. Microbiol. Biotechnol. 59:270-7 Jul 2002. 12111157


  • Calonge M, Pérez-Pertejo Y, Ordóñez C, Reguera RM, Balaña-Fouce R, Ordóñez D. Determinación de residuos de siete insecticidas organofosforados en frutas mediante cromatografía de gases con detector de nitrógeno-fósforo y confirmación por espectrometría de masas. Rev. Toxicol. 2002; 19: 55-60. http://www.redalyc.org/articulo.oa?id=91919201


  • Moralejo, FJ, Cardoza, RE, Gutierrez, S, Lombraña, M, Fierro, F, Martín, JF, Silencing of the aspergillopepsin B (pepB) gene of Aspergillus awamori by antisense RNA expression or protease removal by gene disruption results in a large increase in thaumatin production.Appl. Environ. Microbiol. 68:3550-9 Jul 2002. 12089041


  • Santamarta, I, Rodríguez-García, A, Pérez-Redondo, R, Martín, JF, Liras, P, CcaR is an autoregulatory protein that binds to the ccaR and cefD-cmcI promoters of the cephamycin C-clavulanic acid cluster in Streptomyces clavuligerus.J. Bacteriol. 184:3106-13 Jun 2002. 12003953


  • Mellado, E, Lorenzana, LM, Rodríguez-Sáiz, M, Díez, B, Liras, P, Barredo, JL, The clavulanic acid biosynthetic cluster of Streptomyces clavuligerus: genetic organization of the region upstream of the car gene.Microbiology (Reading, Engl.) 148:1427-38 May 2002. 11988517


  • Fernández, M, Cuadrado, Y, Recio, E, Aparicio, JF, Martín, JF, Characterization of the hom-thrC-thrB cluster in aminoethoxyvinylglycine-producing Streptomyces sp. NRRL 5331.Microbiology (Reading, Engl.) 148:1413-20 May 2002. 11988515


  • Laich, F, Fierro, F, Martín, JF, Production of penicillin by fungi growing on food products: identification of a complete penicillin gene cluster in Penicillium griseofulvum and a truncated cluster in Penicillium verrucosum.Appl. Environ. Microbiol. 68:1211-9 Mar 2002. 11872470


  • Bañuelos, O, Casqueiro, J, Steidl, S, Gutiérrez, S, Brakhage, A, Martín, JF, Subcellular localization of the homocitrate synthase in Penicillium chrysogenum.Mol. Genet. Genomics 266:711-9 Jan 2002. 11810244


  • Reguera, RM, Balaña-Fouce, R, Pérez-Pertejo, Y, Fernández, FJ, García-Estrada, C, Cubría, JC, Ordóñez, C, Ordóñez, D, Cloning expression and characterization of methionine adenosyltransferase in Leishmania infantum promastigotes.J. Biol. Chem. 277:3158-67 Feb 2002. 11698393


  • Velasco, J, Gutiérrez, S, Casqueiro, J, Fierro, F, Campoy, S, Martín, JF, Cloning and characterization of the gene cahB encoding a cephalosporin C acetylhydrolase from Acremonium chrysogenum.Appl. Microbiol. Biotechnol. 57:350-6 Oct 2001. 11759684


  • Naranjo, L, Martin de Valmaseda, E, Bañuelos, O, Lopez, P, Riaño, J, Casqueiro, J, Martin, JF, Conversion of pipecolic acid into lysine in Penicillium chrysogenum requires pipecolate oxidase and saccharopine reductase: characterization of the lys7 gene encoding saccharopine reductase.J. Bacteriol. 183:7165-72 Dec 2001. 11717275


  • Kosalková, K, Marcos, AT, Martín, JF, A moderate amplification of the mecB gene encoding cystathionine-gamma-lyase stimulates cephalosporin biosynthesis in Acremonium chrysogenum.J. Ind. Microbiol. Biotechnol. 27:252-8 Oct 2001. 11687939


  • Moralejo, FJ, Watson, AJ, Jeenes, DJ, Archer, DB, Martín, JF, A defined level of protein disulfide isomerase expression is required for optimal secretion of thaumatin by Aspegillus awamori.Mol. Genet. Genomics 266:246-53 Oct 2001. 11683266


  • Leitão, AL, Enguita, FJ, Martín, JF, Santos Oliveira, JF, Effect of exogenous lysine the expression of early cephamycin C biosynthetic genes and antibiotic production in Nocardia lactamdurans MA4213.Appl. Microbiol. Biotechnol. 56:670-5 Sep 2001. 11601612


  • Bañuelos, O, Casqueiro, J, Gutiérrez, S, Martín, JF, Intrachromosomal recombination after targeted monocopy integration in Penicillium chrysogenum: stabilization of the direct repeats to prevent loss of the inserted gene.Curr. Genet. 39:231-6 Jun 2001. 11453252


  • Mendes, MV, Recio, E, Fouces, R, Luiten, R, Martín, JF, Aparicio, JF, Engineered biosynthesis of novel polyenes: a pimaricin derivative produced by targeted gene disruption in Streptomyces natalensis.Chem. Biol. 8:635-44 Jul 2001. 11451665


  • Hernándo-Rico, V, Martín, JF, Santamarta, I, Liras, P, Structure of the ask-asd operon and formation of aspartokinase subunits in the cephamycin producer ‘Amycolatopsis lactamdurans’.Microbiology (Reading, Engl.) 147:1547-55 Jun 2001. 11390685


  • Moura, RS, Martín, JF, Martín, A, Liras, P, Substrate analysis and molecular cloning of the extracellular alkaline phosphatase of Streptomyces griseus.Microbiology (Reading, Engl.) 147:1525-33 Jun 2001. 11390683


  • Barreiro, C, González-Lavado, E, Martín, JF, Organization and transcriptional analysis of a six-gene cluster around the rplK-rplA operon of Corynebacterium glutamicum encoding the ribosomal proteins L11 and L1.Appl. Environ. Microbiol. 67:2183-90 May 2001. 11319098


  • Hijarrubia, MJ, Aparicio, JF, Casqueiro, J, Martín, JF, Characterization of the lys2 gene of Acremonium chrysogenum encoding a functional alpha-aminoadipate activating and reducing enzyme.Mol. Gen. Genet. 264:755-62 Feb 2001. 11254122


  • Gang, L., Casqueiro, J., Gutiérrez, S., Kosalková, K., Castillo, N.I. and J. F. Martín. Elicitation of penicillin biosynthesis by alginate in Penicillium chrysogenum exerted on pcbAB, pcbC and penDE genes at transriptional level. J. Microbiol. Biotechno. 11, 812-818, 2001.


  • Marcos, AT, Kosalková, K, Cardoza, RE, Fierro, F, Gutiérrez, S, Martín, JF, Characterization of the reverse transsulfuration gene mecB of Acremonium chrysogenum, which encodes a functional cystathionine-gamma-lyase.Mol. Gen. Genet. 264:746-54 Feb 2001. 11254121


  • Liu, G, Casqueiro, J, Bañuelos, O, Cardoza, RE, Gutiérrez, S, Martín, JF, Targeted inactivation of the mecB gene, encoding cystathionine-gamma-lyase, shows that the reverse transsulfuration pathway is required for high-level cephalosporin biosynthesis in Acremonium chrysogenum C10 but not for methionine induction of the cephalosporin genes.J. Bacteriol. 183:1765-72 Mar 2001. 11160109


  • Gutiérrez, S, Casqueiro, J, Martín, JF, [Filamentous fungi as cellular factories: Biodiversity of secondary metabolites].Rev Iberoam Micol 17:S54-60 Mar 2000. 15762783


  • Moralejo, FJ, Cardoza, RE, Gutiérrez, S, Sisniega, H, Faus, I, Martín, JF, Overexpression and lack of degradation of thaumatin in an aspergillopepsin A-defective mutant of Aspergillus awamori containing an insertion in the pepA gene.Appl. Microbiol. Biotechnol. 54:772-7 Dec 2000. 11152068


  • Martin, JF, Alpha-aminoadipyl-cysteinyl-valine synthetases in beta-lactam producing organisms. From Abraham’s discoveries to novel concepts of non-ribosomal peptide synthesis.J. Antibiot. 53:1008-21 Oct 2000. 11132945


  • Aparicio, JF, Fouces, R, Mendes, MV, Olivera, N, Martín, JF, A complex multienzyme system encoded by five polyketide synthase genes is involved in the biosynthesis of the 26-membered polyene macrolide pimaricin in Streptomyces natalensis.Chem. Biol. 7:895-905 Nov 2000. 11094342


  • Liras, P, Rodríguez-García, A, Clavulanic acid, a beta-lactamase inhibitor: biosynthesis and molecular genetics.Appl. Microbiol. Biotechnol. 54:467-75 Oct 2000. 11092620


  • Rodríguez-García, A, de la Fuente, A, Pérez-Redondo, R, Martín, JF, Liras, P, Characterization and expression of the arginine biosynthesis gene cluster of Streptomyces clavuligerus.J. Mol. Microbiol. Biotechnol. 2:543-50 Oct 2000. 11075930


  • Cardoza, RE, Velasco, J, Martín, JF, Liras, P, A cephalosporin C acetylhydrolase is present in the cultures of Nocardia lactamdurans.Appl. Microbiol. Biotechnol. 54:406-12 Sep 2000. 11030579


  • Bañuelos, O, Casqueiro, J, Gutiérrez, S, Martín, JF, Overexpression of the lys1 gene in Penicillium chrysogenum: homocitrate synthase levels, alpha-aminoadipic acid pool and penicillin production.Appl. Microbiol. Biotechnol. 54:69-77 Jul 2000. 10952007


  • Barreiro, C, Pisabarro, A, Martín, JF, Characterization of the ribosomal rrnD operon of the cephamycin-producer ‘Nocardia lactamdurans’ shows that this actinomycete belongs to the genus Amycolatopsis.Syst. Appl. Microbiol. 23:15-24 Apr 2000. 10879974


  • Chary, VK, de la Fuente, JL, Leitão, AL, Liras, P, Martín, JF, Overexpression of the lat gene in Nocardia lactamdurans from strong heterologous promoters results in very high levels of lysine-6-aminotransferase and up to two-fold increase in cephamycin C production.Appl. Microbiol. Biotechnol. 53:282-8 Mar 2000. 10772467


  • Martín, JF, Molecular control of expression of penicillin biosynthesis genes in fungi: regulatory proteins interact with a bidirectional promoter region.J. Bacteriol. 182:2355-62 May 2000. 10762232


  • Amador, E, Martín, JF, Castro, JM, A Brevibacterium lactofermentum 16S rRNA gene used as target site for homologous recombination.FEMS Microbiol. Lett. 185:199-204 Apr 2000. 10754248


  • Bañuelos, O, Casqueiro, J, Gutiérrez, S, Riaño, J, Martín, JF, The specific transport system for lysine is fully inhibited by ammonium in Penicillium chrysogenum: an ammonium-insensitive system allows uptake in carbon-starved cells.Antonie Van Leeuwenhoek 77:91-100 Jan 2000. 10696883


  • Mendes, MV, Aparicio, JF, Martín, JF, Complete nucleotide sequence and characterization of pSNA1 from pimaricin-producing Streptomyces natalensis that replicates by a rolling circle mechanism.Plasmid 43:159-65 Mar 2000. 10686136


  • Kosalková, K, Marcos, AT, Fierro, F, Hernando-Rico, V, Gutiérrez, S, Martín, JF, A novel heptameric sequence (TTAGTAA) is the binding site for a protein required for high level expression of pcbAB, the first gene of the penicillin biosynthesis in Penicillium chrysogenum.J. Biol. Chem. 275:2423-30 Jan 2000. 10644695


  • Reguera, RM, Pérez-Pertejo, Y, Ordóñez, C, Cubría, JC, Tekwani, BL, Balaña-Fouce, R, Ordóñez, D, S-adenosylmethionine synthesis in Leishmania infantum promastigotes.Cell Biol. Int. 23:579-83 1999. 10704242


  • Pérez-Redondo, R, Rodríguez-García, A, Martín, JF, Liras, P, Deletion of the pyc gene blocks clavulanic acid biosynthesis except in glycerol-containing medium: evidence for two different genes in formation of the C3 unit.J. Bacteriol. 181:6922-8 Nov 1999. 10559157


  • Casqueiro, J, Bañuelos, O, Gutiérrez, S, Hijarrubia, MJ, Martín, JF, Intrachromosomal recombination between direct repeats in Penicillium chrysogenum: gene conversion and deletion events.Mol. Gen. Genet. 261:994-1000 Jul 1999. 10485291


  • Liras, P, Biosynthesis and molecular genetics of cephamycins. Cephamycins produced by actinomycetes.Antonie Van Leeuwenhoek 75:109-24.10422584


  • Gutiérrez, S, Fierro, F, Casqueiro, J, Martín, JF, Gene organization and plasticity of the beta-lactam genes in different filamentous fungi.Antonie Van Leeuwenhoek 75:81-94. 10422582


  • Martín, JF, Casqueiro, J, Kosalková, K, Marcos, AT, Gutiérrez, S, Penicillin and cephalosporin biosynthesis: mechanism of carbon catabolite regulation of penicillin production.Antonie Van Leeuwenhoek 75:21-31.10422579


  • Cubría, JC, Ordóñez, C, Reguera, RM, Tekwani, BL, Balaña-Fouce, R, Ordóñez, D, Early alterations of polyamine metabolism induced after acute administration of clenbuterol in mouse heart.Life Sci. 64:1739-52 1999. 10353628


  • Fierro, F, Martín, JF, Molecular mechanisms of chromosomal rearrangement in fungi.Crit. Rev. Microbiol. 25:1-17 1999. 10342097


  • Amador, E, Castro, JM, Correia, A, Martín, JF, Structure and organization of the rrnD operon of ‘Brevibacterium lactofermentum’: analysis of the 16S rRNA gene.Microbiology (Reading, Engl.) 145 ( Pt 4):915-24 Apr 1999. 10220171


  • Leitão, AL, Enguita, FJ, De La Fuente, JL, Liras, P, Martin, JF, Inducing effect of diamines on transcription of the cephamycin C genes from the lat and pcbAB promoters in Nocardia lactamdurans.J. Bacteriol. 181:2379-84 Apr 1999. 10197999


  • Aparicio, JF, Colina, AJ, Ceballos, E, Martín, JF, The biosynthetic gene cluster for the 26-membered ring polyene macrolide pimaricin. A new polyketide synthase organization encoded by two subclusters separated by functionalization genes.J. Biol. Chem. 274:10133-9 Apr 1999. 10187796


  • Gutiérrez, S, Marcos, AT, Casqueiro, J, Kosalková, K, Fernández, FJ, Velasco, J, Martín, JF, Transcription of the pcbAB, pcbC and penDE genes of Penicillium chrysogenum AS-P-78 is repressed by glucose and the repression is not reversed by alkaline pHs.Microbiology (Reading, Engl.) 145 ( Pt 2):317-24 Feb 1999. 10075414


  • Laich, F, Fierro, F, Cardoza, RE, Martin, JF, Organization of the gene cluster for biosynthesis of penicillin in Penicillium nalgiovense and antibiotic production in cured dry sausages.Appl. Environ. Microbiol. 65:1236-40 Mar 1999. 10049889


  • Moralejo, FJ, Cardoza, RE, Gutierrez, S, Martin, JF, Thaumatin production in Aspergillus awamori by use of expression cassettes with strong fungal promoters and high gene dosage.Appl. Environ. Microbiol. 65:1168-74 Mar 1999. 10049878


  • Casqueiro, J, Gutiérrez, S, Bañuelos, O, Hijarrubia, MJ, Martín, JF, Gene targeting in Penicillium chrysogenum: disruption of the lys2 gene leads to penicillin overproduction.J. Bacteriol. 181:1181-8 Feb 1999. 9973344


  • Velasco, J, Gutierrez, S, Campoy, S, Martin, JF, Molecular characterization of the Acremonium chrysogenum cefG gene product: the native deacetylcephalosporin C acetyltransferase is not processed into subunits.Biochem. J. 337 ( Pt 3):379-85 Feb 1999. 9895280


  • Bañuelos, O, Casqueiro, J, Fierro, F, Hijarrubia, MJ, Gutiérrez, S, Martín, JF, Characterization and lysine control of expression of the lys1 gene of Penicillium chrysogenum encoding homocitrate synthase.Gene 226:51-9 Jan 1999. 9889317


  • Liras, P, Rodríguez-García, A, Martín, JF, Evolution of the clusters of genes for beta-lactam antibiotics: a model for evolutive combinatorial assembly of new beta-lactams.Int. Microbiol. 1:271-8 Dec 1998. 10943374


  • Blanco, J, Driessen, AJ, Coque, JJ, Martin, JF, Biochemical characterization of the SecA protein of Streptomyces lividans–interaction with nucleotides, binding to membrane vesicles and in vitro translocation of proAmy protein.Eur. J. Biochem. 257:472-8 Oct 1998. 9826195


  • Cepero, M, Cubría, JC, Reguera, R, Balaña-Fouce, R, Ordóñez, C, Ordóñez, D, Plasma and muscle polyamine levels in aerobically exercised rats treated with salbutamol.J. Pharm. Pharmacol. 50:1059-64 Sep 1998. 9811168


  • Casqueiro, J, Gutiérrez, S, Bañuelos, O, Fierro, F, Velasco, J, Martín, JF, Characterization of the lys2 gene of Penicillium chrysogenum encoding alpha-aminoadipic acid reductase.Mol. Gen. Genet. 259:549-56 Sep 1998. 9790587


  • Enguita, FJ, Coque, JJ, Liras, P, Martin, JF, The nine genes of the Nocardia lactamdurans cephamycin cluster are transcribed into large mRNAs from three promoters, two of them located in a bidirectional promoter region.J. Bacteriol. 180:5489-94 Oct 1998. 9765587


  • Pérez-Llarena, FJ, Rodríguez-García, A, Enguita, FJ, Martín, JF, Liras, P, The pcd gene encoding piperideine-6-carboxylate dehydrogenase involved in biosynthesis of alpha-aminoadipic acid is located in the cephamycin cluster of Streptomyces clavuligerus.J. Bacteriol. 180:4753-6 Sep 1998. 9721323


  • Martín, JF, New aspects of genes and enzymes for beta-lactam antibiotic biosynthesis.Appl. Microbiol. Biotechnol. 50:1-15 Jul 1998. 9720195


  • Johnson, R, Cubría, JC, Reguera, RM, Balaña-Fouce, R, Ordóñez, D, Interaction of cationic diamidines with Leishmania infantum DNA.Biol. Chem. 379:925-30 Jul 1998. 9705158


  • Cardoza, RE, Moralejo, FJ, Gutiérrez, S, Casqueiro, J, Fierro, F, Martín, JF, Characterization and nitrogen-source regulation at the transcriptional level of the gdhA gene of Aspergillus awamori encoding an NADP-dependent glutamate dehydrogenase.Curr. Genet. 34:50-9 Jul 1998. 9683675


  • Pérez-Redondo, R, Rodríguez-García, A, Martín, JF, Liras, P, The claR gene of Streptomyces clavuligerus, encoding a LysR-type regulatory protein controlling clavulanic acid biosynthesis, is linked to the clavulanate-9-aldehyde reductase (car) gene.Gene 211:311-21 May 1998. 9602162


  • Pisabarro, A, Correia, A, Martín, JF, Pulsed-field gel electrophoresis analysis of the genome of Rhodococcus fascians: genome size and linear and circular replicon composition in virulent and avirulent strains.Curr. Microbiol. 36:302-8 May 1998. 9541568


  • Balaña-Fouce, R, Reguera, RM, Cubría, JC, Ordóñez, D, The pharmacology of leishmaniasis.Gen. Pharmacol. 30:435-43 Apr 1998. 9580315


  • Cubría, JC, Reguera, R, Balaña-Fouce, R, Ordóñez, C, Ordóñez, D, Polyamine-mediated heart hypertrophy induced by clenbuterol in the mouse.J. Pharm. Pharmacol. 50:91-6 Jan 1998. 9580224


  • Pisabarro, A, Correia, A, Martín, JF, Characterization of the rrnB operon of the plant pathogen Rhodococcus fascians and targeted integrations of exogenous genes at rrn loci.Appl. Environ. Microbiol. 64:1276-82 Apr 1998. 9546162


  • Blanco, J, Coque, JJ, Martin, JF, The folate branch of the methionine biosynthesis pathway in Streptomyces lividans: disruption of the 5,10-methylenetetrahydrofolate reductase gene leads to methionine auxotrophy.J. Bacteriol. 180:1586-91 Mar 1998. 9515933


  • Gutiérrez, S, Velasco, J, Marcos, AT, Fernández, FJ, Fierro, F, Barredo, JL, Díez, B, Martín, JF, Expression of the cefG gene is limiting for cephalosporin biosynthesis in Acremonium chrysogenum.Appl. Microbiol. Biotechnol. 48:606-14 Nov 1997. 9421924


  • de La Fuente, JL, Rumbero, A, Martín, JF, Liras, P, Delta-1-piperideine-6-carboxylate dehydrogenase, a new enzyme that forms alpha-aminoadipate in Streptomyces clavuligerus and other cephamycin C-producing actinomycetes.Biochem. J. 327 ( Pt 1):59-64 Oct 1997. 9355735


  • Pérez-Llarena, F, Martín, JF, Galleni, M, Coque, JJ, Fuente, JL, Frère, JM, Liras, P, The bla gene of the cephamycin cluster of Streptomyces clavuligerus encodes a class A beta-lactamase of low enzymatic activity.J. Bacteriol. 179:6035-40 Oct 1997. 9324249


  • Blanco, J, Coque, JJ, Velasco, J, Martín, JF, Cloning, expression in Streptomyces lividans and biochemical characterization of a thermostable endo-beta-1,4-xylanase of Thermomonospora alba ULJB1 with cellulose-binding ability.Appl. Microbiol. Biotechnol. 48:208-17 Aug 1997. 9299779


  • Hijarrubia, MJ, Casqueiro, J, Gutiérrez, S, Fernández, FJ, Martín, JF, Characterization of the bip gene of Aspergillus awamori encoding a protein with an HDEL retention signal homologous to the mammalian BiP involved in polypeptide secretion.Curr. Genet. 32:139-46 Aug 1997. 9294262


  • Oguiza, JA, Marcos, AT, Martín, JF, Transcriptional analysis of the sigA and sigB genes of Brevibacterium lactofermentum.FEMS Microbiol. Lett. 153:111-7 Aug 1997. 9252580


  • Chary, VK, de la Fuente, JL, Liras, P, Martin, JF, Amy as a reporter gene for promoter activity in Nocardia lactamdurans: comparison of promoters of the cephamycin cluster.Appl. Environ. Microbiol. 63:2977-82 Aug 1997. 9251185


  • Rodríguez-García, A, Ludovice, M, Martín, JF, Liras, P, Arginine boxes and the argR gene in Streptomyces clavuligerus: evidence for a clear regulation of the arginine pathway.Mol. Microbiol. 25:219-28 Jul 1997. 9282734


  • Romero, J, Martín, JF, Liras, P, Demain, AL, Rius, N, Partial purification, characterization and nitrogen regulation of the lysine epsilon-aminotransferase of Streptomyces clavuligerus.J. Ind. Microbiol. Biotechnol. 18:241-6 Apr 1997. 9172431


  • Pérez-Llarena, FJ, Liras, P, Rodríguez-García, A, Martín, JF, A regulatory gene (ccaR) required for cephamycin and clavulanic acid production in Streptomyces clavuligerus: amplification results in overproduction of both beta-lactam compounds.J. Bacteriol. 179:2053-9 Mar 1997. 9068654


  • Enguita, FJ, Liras, P, Leitão, AL, Martín, JF, Interaction of the two proteins of the methoxylation system involved in cephamycin C biosynthesis. Immunoaffinity, protein cross-linking, and fluorescence spectroscopy studies.J. Biol. Chem. 271:33225-30 Dec 1996. 8969179


  • Calonge M, Bayoumi AE, Cubría JC, Balaña-Fouce R and Ordóñez D. Effects of cationics diamidines on polyamine metabolis in the Trypanomatid Crithidia fasciculate. Life Sci.1996; 59 (12): 191. 8809218

    • Year: 1996
    • Related applications: Health


  • Fernández-González, C, Gil, JA, Mateos, LM, Schwarzer, A, Schäfer, A, Kalinowski, J, Pühler, A, Martín, JF, Construction of L-lysine-overproducing strains of Brevibacterium lactofermentum by targeted disruption of the hom and thrB genes.Appl. Microbiol. Biotechnol. 46:554-8 Dec 1996. 9008889


  • Coque, JJ, de la Fuente, JL, Liras, P, Martín, JF, Overexpression of the Nocardia lactamdurans alpha-aminoadipyl-cysteinyl-valine synthetase in Streptomyces lividans. The purified multienzyme uses cystathionine and 6-oxopiperidine 2-carboxylate as substrates for synthesis of the tripeptide.Eur. J. Biochem. 242:264-70 Dec 1996. 8973642


  • De la Fuente, JL, Martin, JF, Liras, P, New type of hexameric ornithine carbamoyltransferase with arginase activity in the cephamycin producers Streptomyces clavuligerus and Nocardia lactamdurans.Biochem. J. 320 ( Pt 1):173-9 Nov 1996. 8947483


  • Oguiza, JA, Marcos, AT, Malumbres, M, Martín, JF, The galE gene encoding the UDP-galactose 4-epimerase of Brevibacterium lactofermentum is coupled transcriptionally to the dmdR gene.Gene 177:103-7 Oct 1996. 8921853


  • Blanco, J, Coque, JJ, Martín, JF, Characterization of the secA gene of Streptomyces lividans encoding a protein translocase which complements and Escherichia coli mutant defective in the ATPase activity of SecA.Gene 176:61-5 Oct 1996. 8918233


  • Malumbres, M, Martín, JF, Molecular control mechanisms of lysine and threonine biosynthesis in amino acid-producing corynebacteria: redirecting carbon flow.FEMS Microbiol. Lett. 143:103-14 Oct 1996. 8837462


  • Mateos, LM, Schäfer, A, Kalinowski, J, Martin, JF, Pühler, A, Integration of narrow-host-range vectors from Escherichia coli into the genomes of amino acid-producing corynebacteria after intergeneric conjugation.J. Bacteriol. 178:5768-75 Oct 1996. 8824624


  • Kumar, V, de la Fuente, JL, Leitão, AL, Liras, P, Martín, JF, Effect of amplification or targeted disruption of the beta-lactamase gene of Nocardia lactamdurans on cephamycin biosynthesis.Appl. Microbiol. Biotechnol. 45:621-8 Jun 1996. 8766697


  • Correia, A, Pisabarro, A, Castro, JM, Martín, JF, Cloning and characterization of an IS-like element present in the genome of Brevibacterium lactofermentum ATCC 13869.Gene 170:91-4 Apr 1996. 8621097


  • Enguita, FJ, de la Fuente, JL, Martín, JF, Liras, P, An inducible expression system of histidine-tagged proteins in Streptomyces lividans for one-step purification by Ni2+ affinity chromatography.FEMS Microbiol. Lett. 137:135-40 Apr 1996. 8998975


  • Calonge, M, Cubría, JC, Balaña-Fouce, R, Ordóñez, D, Putrescine active uptake system in the Trypanosomatid Crithidia fasciculata.Biol. Chem. Hoppe-Seyler 377:233-8 Apr 1996. 8737988


  • Fierro, F, Kosalková, K, Gutiérrez, S, Martin, JF, Autonomously replicating plasmids carrying the AMA1 region in Penicillium chrysogenum.Curr. Genet. 29:482-9 Apr 1996. 8625429


  • Cadenas, RF, Fernández-González, C, Martín, JF, Gil, JA, Construction of new cloning vectors for Brevibacterium lactofermentum.FEMS Microbiol. Lett. 137:63-8 Mar 1996. 8935658


  • Coque, JJ, Enguita, FJ, Cardoza, RE, Martín, JF, Liras, P, Characterization of the cefF gene of Nocardia lactamdurans encoding a 3′-methylcephem hydroxylase different from the 7-cephem hydroxylase.Appl. Microbiol. Biotechnol. 44:605-9 Jan 1996. 8703431


  • Fierro, F, Montenegro, E, Gutiérrez, S, Martín, JF, Mutants blocked in penicillin biosynthesis show a deletion of the entire penicillin gene cluster at a specific site within a conserved hexanucleotide sequence.Appl. Microbiol. Biotechnol. 44:597-604 Jan 1996. 8703430


  • Oguiza, JA, Marcos, AT, Malumbres, M, Martín, JF, Multiple sigma factor genes in Brevibacterium lactofermentum: characterization of sigA and sigB.J. Bacteriol. 178:550-3 Jan 1996. 8550480


  • Rodríguez-García, A, Martín, JF, Liras, P, The argG gene of Streptomyces clavuligerus has low homology to unstable argG from other actinomycetes: effect of amplification on clavulanic acid biosynthesis.Gene 167:9-15 Dec 1995. 8566818


  • Coque, JJ, Pérez-Llarena, FJ, Enguita, FJ, Fuente, JL, Martín, JF, Liras, P, Characterization of the cmcH genes of Nocardia lactamdurans and Streptomyces clavuligerus encoding a functional 3′-hydroxymethylcephem O-carbamoyltransferase for cephamycin biosynthesis.Gene 162:21-7 Aug 1995. 7557411


  • Fierro, F, Barredo, JL, Díez, B, Gutierrez, S, Fernández, FJ, Martín, JF, The penicillin gene cluster is amplified in tandem repeats linked by conserved hexanucleotide sequences.Proc. Natl. Acad. Sci. U.S.A. 92:6200-4 Jun 1995. 7597101


  • Coque, JJ, Enguita, FJ, Martín, JF, Liras, P, A two-protein component 7 alpha-cephem-methoxylase encoded by two genes of the cephamycin C cluster converts cephalosporin C to 7-methoxycephalosporin C.J. Bacteriol. 177:2230-5 Apr 1995. 7721717


  • Marcos, AT, Gutiérrez, S, Díez, B, Fernández, FJ, Oguiza, JA, Martín, JF, Three genes hrdB, hrdD and hrdT of Streptomyces griseus IMRU 3570, encoding sigma factor-like proteins, are differentially expressed under specific nutritional conditions.Gene 153:41-8 Feb 1995. 7883183


  • Malumbres, M, Mateos, LM, Guerrero, C, Martín, JF, Molecular cloning of the hom-thrC-thrB cluster from Bacillus sp. ULM1: expression of the thrC gene in Escherichia coli and corynebacteria, and evolutionary relationships of the threonine genes.Folia Microbiol. (Praha) 40:595-606 1995. 8768250


  • Oguiza, JA, Tao, X, Marcos, AT, Martín, JF, Murphy, JR, Molecular cloning, DNA sequence analysis, and characterization of the Corynebacterium diphtheriae dtxR homolog from Brevibacterium lactofermentum.J. Bacteriol. 177:465-7 Jan 1995. 7814338


  • Martín, JF, Gutiérrez, S, Genes for beta-lactam antibiotic biosynthesis.Antonie Van Leeuwenhoek 67:181-200 1995. 7771766


  • Mateos, LM, Pisabarro, A, Pátek, M, Malumbres, M, Guerrero, C, Eikmanns, BJ, Sahm, H, Martín, JF, Transcriptional analysis and regulatory signals of the hom-thrB cluster of Brevibacterium lactofermentum.J. Bacteriol. 176:7362-71 Dec 1994. 7961509


  • Kumar, CV, Coque, JJ, Martín, JF, Efficient Transformation of the Cephamycin C Producer Nocardia lactamdurans and Development of Shuttle and Promoter-Probe Cloning Vectors.Appl. Environ. Microbiol. 60:4086-93 Nov 1994. 16349436


  • Correia, A, Martín, JF, Castro, JM, Pulsed-field gel electrophoresis analysis of the genome of amino acid producing corynebacteria: chromosome sizes and diversity of restriction patterns.Microbiology (Reading, Engl.) 140 ( Pt 10):2841-7 Oct 1994. 8000547


  • Fernández, FJ, Gutierrez, S, Velasco, J, Montenegro, E, Marcos, AT, Martín, JF, Molecular characterization of three loss-of-function mutations in the isopenicillin N-acyltransferase gene (penDE) of Penicillium chrysogenum.J. Bacteriol. 176:4941-8 Aug 1994. 7519594


  • Malumbres, M, Mateos, LM, Lumbreras, MA, Guerrero, C, Martín, JF, Analysis and expression of the thrC gene of Brevibacterium lactofermentum and characterization of the encoded threonine synthase.Appl. Environ. Microbiol. 60:2209-19 Jul 1994. 8074505


  • Fernandez-Gonzalez, C, Cadenas, RF, Noirot-Gros, MF, Martin, JF, Gil, JA, Characterization of a region of plasmid pBL1 of Brevibacterium lactofermentum involved in replication via the rolling circle model.J. Bacteriol. 176:3154-61 Jun 1994. 8195068


  • Esmahan, C, Alvarez, E, Montenegro, E, Martin, JF, Catabolism of lysine in Penicillium chrysogenum leads to formation of 2-aminoadipic acid, a precursor of penicillin biosynthesis.Appl. Environ. Microbiol. 60:1705-10 Jun 1994. 8031073


  • Vigal, T, Martin, JF, Gil, JA, Expression of the Streptomyces griseus alpha-amylase gene in Escherichia coli.FEMS Microbiol. Lett. 118:259-63 May 1994. 8020751


  • Asturias, JA, Martín, JF, Liras, P, Biosynthesis and phosphate control of candicidin by Streptomyces acrimycini JI2236: effect of amplification of the pabAB gene.J. Ind. Microbiol. 13:183-9 May 1994. 7764844


  • Liras, P, Coque, JJ, García-Calzada, J, Pérez Llarena, FJ, Cardoza, RE, [Grouping of the genes of biosynthesis and resistance to beta-lactam antibiotics in cephamycin-C producing actinomycetes].Microbiologia 10:49-56. 7946127


  • Velasco, J, Gutierrez, S, Fernandez, FJ, Marcos, AT, Arenos, C, Martin, JF, Exogenous methionine increases levels of mRNAs transcribed from pcbAB, pcbC, and cefEF genes, encoding enzymes of the cephalosporin biosynthetic pathway, in Acremonium chrysogenum.J. Bacteriol. 176:985-91 Feb 1994. 8106341


  • Guerrero, C, Mateos, LM, Malumbres, M, Martín, JF, Directed mutagenesis of a regulatory palindromic sequence upstream from the Brevibacterium lactofermentum tryptophan operon.Gene 138:35-41 Jan 1994. 7510262


  • Martín, JF, Gutiérrez, S, Fernández, FJ, Velasco, J, Fierro, F, Marcos, AT, Kosalkova, K, Expression of genes and processing of enzymes for the biosynthesis of penicillins and cephalosporins.Antonie Van Leeuwenhoek 65:227-43 1994. 7847890


  • Fierro, F, Gutiérrez, S, Díez, B, Martín, JF, Resolution of four large chromosomes in penicillin-producing filamentous fungi: the penicillin gene cluster is located on chromosome II (9.6 Mb) in Penicillium notatum and chromosome I (10.4 Mb) in Penicillium chrysogenum.Mol. Gen. Genet. 241:573-8 Dec 1993. 8264531


  • Malumbres, M, Gil, JA, Martín, JF, Codon preference in corynebacteria.Gene 134:15-24 Nov 1993. 8244028


  • Oguiza, JA, Malumbres, M, Eriani, G, Pisabarro, A, Mateos, LM, Martin, F, Martín, JF, A gene encoding arginyl-tRNA synthetase is located in the upstream region of the lysA gene in Brevibacterium lactofermentum: regulation of argS-lysA cluster expression by arginine.J. Bacteriol. 175:7356-62 Nov 1993. 8226683


  • Alvarez, E, Meesschaert, B, Montenegro, E, Gutiérrez, S, Díez, B, Barredo, JL, Martín, JF, The isopenicillin-N acyltransferase of Penicillium chrysogenum has isopenicillin-N amidohydrolase, 6-aminopenicillanic acid acyltransferase and penicillin amidase activities, all of which are encoded by the single penDE gene.Eur. J. Biochem. 215:323-32 Jul 1993. 8344300


  • Pisabarro, A, Malumbres, M, Mateos, LM, Oguiza, JA, Martín, JF, A cluster of three genes (dapA, orf2, and dapB) of Brevibacterium lactofermentum encodes dihydrodipicolinate synthase, dihydrodipicolinate reductase, and a third polypeptide of unknown function.J. Bacteriol. 175:2743-9 May 1993. 8478336


  • Criado, LM, Martín, JF, Gil, JA, The pab gene of Streptomyces griseus, encoding p-aminobenzoic acid synthase, is located between genes possibly involved in candicidin biosynthesis.Gene 126:135-9 Apr 1993. 8472954


  • Coque, JJ, Liras, P, Martín, JF, Genes for a beta-lactamase, a penicillin-binding protein and a transmembrane protein are clustered with the cephamycin biosynthetic genes in Nocardia lactamdurans.EMBO J. 12:631-9 Feb 1993. 8440253


  • Cantoral, JM, Gutiérrez, S, Fierro, F, Gil-Espinosa, S, van Liempt, H, Martín, JF, Biochemical characterization and molecular genetics of nine mutants of Penicillium chrysogenum impaired in penicillin biosynthesis.J. Biol. Chem. 268:737-44 Jan 1993. 8416976


  • Coque, JJ, Martín, JF, Liras, P, Characterization and expression in Streptomyces lividans of cefD and cefE genes from Nocardia lactamdurans: the organization of the cephamycin gene cluster differs from that in Streptomyces clavuligerus.Mol. Gen. Genet. 236:453-8 Jan 1993. 8437592